Oxytocin Effects on Self and Other Processing

Not Applicable

Completed

• Conditions: Social Behavior
• Interventions: Drug: Placebo; Drug: Oxytocin

• Registration Number: NCT02963194
• Lead Sponsor: University of Electronic Science and Technology of China

Brief Summary

To determine whether the neuropeptide oxytocin (OXT) influences self-processing by investigating whether it increases the endowment effect in relation to both self and others.

Detailed Description

In a double-blind, between- subject placebo (PLC) controlled design, investigator aimed to measure the effect of intranasal OXT on the endowment effect. All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety before self-administration: Positive and Negative Affect Schedule (PANAS) , State-Trait Anxiety Inventory (STAI) , Beck Depression Inventory (BDI), self-esteem scale (SES). Subjects were asked to decide whether to buy or sell their own or others' (their mothers'/ fathers'/ classmate'/ strangers') possessions at various prices. Indifference point and brain activation were inluded into analysis as dependent variables.

Study Timeline

• Study Start: 2015-11
• Primary Completion: 2016-03
• Study First Submitted: 2016-04-15
• Study Completion: 2016-06
• Status Verified: 2016-11
• Study First Submitted QC: 2016-11-09
• Last Update Submitted: 2016-11-09
• Study First Posted: 2016-11-15
• Last Update Posted: 2016-11-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 44

Inclusion Criteria

• healthy subjects without past or current psychiatric or neurological disorders

Exclusion Criteria

• history of head injury;
• claustrophobia;
• medical or psychiatric illness.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	Placebo nasal spray
Oxytocin	Oxytocin	Oxytoxin nasal spray

Primary Outcome Measures

Name	Time	Method
Compared the indifference point between buy and sell conditions during the price phase and the specific brain region activation between oxytocin and placebo groups	1 hour	Indifference point is the gap between willingness to accept and willingness to pay ;focus on the specfic brain region relasted to self-processing, such as medial prefrontal cortex, precuneus, posterior cingulate cortex, ventral striatum.

Trial Locations

Locations (1)

School of Life Science and Technology, University of Electronic Science and Technology; 🇨🇳 Chengdu, Sichuan, China