The effect of synbiotic supplement in migraine

Not Applicable

Recruiting

• Conditions: Migraine.; Migraine without aura; G43.0

• Registration Number: IRCT20121216011763N45
• Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 30 November 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

Patients who agree to participate in the study
Diagnosis of migraine by a neurologist according to ICHD-3
Aged between 20 to 50 years old

Exclusion Criteria

Non-compliance with dietary recommendations and supplements(Use less than 80% of the prescribed supplement)
Reaction and sensitivity to the prescribed supplement
Lack of referral in different stages of study

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Migraine symptoms (severity, frequency, duration of migraine). Timepoint: At baseline and after 12 weeks. Method of measurement: Questionnaire (Visual analogue scale (VAS) and Clinical examination).;Serum levels of Zonulin. Timepoint: At baseline and after 12 weeks. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kits.;Serum levels of High sensitive C-reactive protein (Hs-CRP). Timepoint: At baseline and after 12 weeks. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kits.

Secondary Outcome Measures

Name	Time	Method
Depression, stress, anxiety. Timepoint: At baseline and after 12 weeks. Method of measurement: DASS-21questionnaire.;Quality of Life in Migraine Patients. Timepoint: At baseline and after 12 weeks. Method of measurement: Migraine –Specific Quality of Life(MSQ)questionnaire.;Serum Nitric Oxide. Timepoint: At baseline and after 12 weeks. Method of measurement: biochemical kit of KiaZist Co.;Total antioxidant capacity. Timepoint: At baseline and after 12 weeks. Method of measurement: biochemical kit of KiaZist Co.;Total oxidant status. Timepoint: At baseline and after 12 weeks. Method of measurement: biochemical kit of KiaZist Co.