The Cognitive Enhancing Effects of D-Cycloserine Among Non-Demented Elderly
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- California Verbal Learning Test-II (CLVT-II)
研究概览
简要总结
The goal of this study is to determine whether a study medication (d-cycloserine) improves the ability of older adults to perform on tests of neuropsychological functioning. Tests of neuropsychological functioning assess attention, memory, and executive functioning skills (for example, problem-solving, planning and organizing skills). It was hypothesized that participants who received study medication would perform better on neuropsychological tests than would participants who received the sugar pill.
详细描述
Accumulating data support the augmenting effects of d-cycloserine (DCS) when combined with exposure-based treatment for anxiety disorders. Additional research is needed to determine whether DCS facilitates other forms of cognitive processing (e.g., attention, memory, executive functioning) that are involved in cognitive behavioral therapies which do not rely on extinction as a mechanism of action. This question is particularly important among older adults who have experienced normal age-related declines in cognitive functioning, which may interfere with their ability to benefit from cognitive-behavioral therapies. The aim of the current study was to determine the cognitive enhancing effects of DCS on neuropsychological test performance among healthy older adults. It was hypothesized that participants who received d-cycloserine would demonstrate superior performance on neuropsychological tests than would participants who received placebo.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age 60 or older
- •native English speaker
排除标准
- •diagnosis of current psychiatric disorder
- •substance abuse past 3 months
- •cognitive impairment
- •neurological disorder
- •poor health or unstable medical condition
- •positive toxicology screen
- •current use of isoniazid
- •current use of trecator
- •severe renal insufficiency
研究组 & 干预措施
Medication
250 mg d-cycloserine
干预措施: d-cycloserine (Drug)
Sugar Pill
干预措施: Sugar Pill (Drug)
结局指标
主要结局
California Verbal Learning Test-II (CLVT-II)
时间窗: Outcome measures will be collected during a single neuropsychological testing administration lasting approximately 3 hours without patient follow up. Scores for the experimental and control group were compared.
The CLVT-II is an assessment of verbal learning and memory which measures recall and recognition scores, encoding strategies, learning rates and error types. A list learning task with 16 words from 4 semantic categories are read over a series of 5 list presentations. Recall is assessed after learning and at a 20-minute delay. Software produces a report that computes raw and standardized scores. Our dependent variable was the age adjusted t-score for total number of words recalled after 5 trials. A higher score indicated better recall. The maximum possible score was 80 and a minimum was 0.
次要结局
- Continuous Performance Test(Outcome measures will be collected during a single neuropsychological testing administration lasting approximately 3 hours without further patient follow-up)
- Wisconsin Card Sort Test(Outcome measures will be collected during a single neuropsychological testing administration lasting approximately 3 hours without further patient follow-up)
- Trails B(Outcome measures will be collected during a single neuropsychological testing administration lasting approximately 3 hours without further patient follow-up)
- Stroop(Outcome measures will be collected during a single neuropsychological testing administration lasting approximately 3 hours without further patient follow-up)
- Controlled Oral Word Association Test(Outcome measures will be collected during a single neuropsychological testing administration lasting approximately 3 hours without further patient follow-up)
- Implicit Memory Task(Outcome measures will be collected during a single neuropsychological testing administration lasting approximately 3 hours without further patient follow-up)