NCT01680107终止3 期
The Effect of a Single-dose of D-cycloserine on the Basic Effects of Cognitive-behaviour Therapy for Panic Disorder - a Randomized Placebo-controlled Trial
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 终止
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- self-reported and clinician-rated anxiety and depression measures
研究概览
简要总结
The purpose of this study is to determine whether d-cycloserine augments the clinical effects of exposure-based cognitive-behaviour therapy for panic disorder.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •clinical diagnosis of panic disorder
- •at least moderate agoraphobic avoidance
排除标准
- •psychoactive medication last 6 weeks
- •exposure-based cognitive-behaviour treatment for panic disorder and agoraphobia during last 3 months
- •female participant who is pregnant or breast-feeding
- •lifetime history of psychosis, bipolar disorder, alcohol, medication or drug abuse or dependence; current primary depressive disorder
- •lifetime history of epilepsy or other significant disease or disorder
研究组 & 干预措施
d-cycloserine
Experimental
oral, capsule, 250 mg, once
干预措施: d-cycloserine (Drug)
d-cycloserine
Experimental
oral, capsule, 250 mg, once
干预措施: cognitive-behaviour therapy (Behavioral)
sugar pill
Placebo Comparator
oral, capsule, once
干预措施: placebo (Drug)
sugar pill
Placebo Comparator
oral, capsule, once
干预措施: cognitive-behaviour therapy (Behavioral)
结局指标
主要结局
self-reported and clinician-rated anxiety and depression measures
时间窗: 6 months
次要结局
- emotional information processing(1 day)
研究者
研究点 (1)
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