The Effect of a Single-dose of D-cycloserine on the Basic Effects of Cognitive-behaviour Therapy for Panic Disorder - a Randomized Placebo-controlled Trial

University of Oxford1 site in 1 country33 target enrollmentOctober 2012

ConditionsPanic Disorder

Interventionsd-cycloserine cognitive-behaviour therapy placebo

Drugsd-cycloserine placebo

Overview

Phase: Phase 3
Intervention: d-cycloserine
Conditions: Panic Disorder
Sponsor: University of Oxford
Enrollment: 33
Locations: 1
Primary Endpoint: self-reported and clinician-rated anxiety and depression measures
Status: Terminated
Last Updated: 8 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to determine whether d-cycloserine augments the clinical effects of exposure-based cognitive-behaviour therapy for panic disorder.

Registry

clinicaltrials.gov

Start Date

October 2012

End Date

April 30, 2018

Last Updated

8 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University of Oxford

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•clinical diagnosis of panic disorder
•at least moderate agoraphobic avoidance

Exclusion Criteria

•psychoactive medication last 6 weeks
•exposure-based cognitive-behaviour treatment for panic disorder and agoraphobia during last 3 months
•female participant who is pregnant or breast-feeding
•lifetime history of psychosis, bipolar disorder, alcohol, medication or drug abuse or dependence; current primary depressive disorder
•lifetime history of epilepsy or other significant disease or disorder