The Effect of Blueberry Consumption on Brain Health in Older Adults: in Vivo Measures of Cerebral Antioxidant and Cerebral Blood Flow
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 63
- 试验地点
- 2
- 主要终点
- Change in cerebral blood flow (CBF)
研究概览
简要总结
The purpose of this study is to determine if increased blueberry intake helps increase brain antioxidant (glutathione) and cerebral blood flow in older adults.
详细描述
Consuming blueberries may improve brain health of older adults by increasing the antioxidant levels in the brain to protect nerve cells in the aging brain. Researchers think that there may be a relationship between the brain's antioxidant defense system and blueberry intake due to the high antioxidant content in blueberries.
This study will investigate if blueberry intake may aid in enhancing glutathione levels and cerebral blood flow using special Magnetic Resonance Imaging (MRI) scans.
Participants will be asked to make a total of up to 4 visits to the research site. Participation will last about 3 months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 65 Years 至 89 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Speak English as the primary language and be able to read and write.
- •Good general health with no concomitant diseases
- •Low berry consumption (≤1 serving/week)
- •Cognitively normal (Mini-Mental State Exam Score ≥24)
- •BMI range=18.5-35 kg/m2.
排除标准
- •Presence of any central neurological diseases or prior major head trauma with loss of consciousness
- •Presence of an active unstable and life-threatening systemic illness
- •Presence of major psychiatric disorders within the past 3 years including depression, anxiety, and alcohol or drug abuse
- •Presence of diabetes mellitus; metabolic syndrome or uncontrolled hypertension
- •Use of psychoactive and investigational medications
- •MRI contraindications (pacemaker, aneurysm clips, artificial heart valves, metal fragments, foreign objects or claustrophobia)
- •Blueberry or salicylate allergy
- •Pregnancy
结局指标
主要结局
Change in cerebral blood flow (CBF)
时间窗: Change from baseline to 3 months
Measure of CBF with a 3 T MRI scanner
Change in brain glutathione (GSH) levels
时间窗: Change from baseline to 3 months
Measure of brain GSH with a 3 T MRI scanner
次要结局
未报告次要终点
研究者
In-Young Choi, Ph.D.
Professor of Neurology
University of Kansas Medical Center