Effects of Blueberry Juice Consumption on Cognitive Function in Healthy Older People

Not Applicable

Completed

• Conditions: Cognitive Aging
• Interventions: Dietary Supplement: Blueberry; Dietary Supplement: Placebo

• Registration Number: NCT02985580
• Lead Sponsor: University of Exeter

Brief Summary

Blueberries are rich in flavonoids that possess antioxidant and anti-inflammatory properties, which in rodent models are neuro-protective. The risk of developing dementia is reduced in people habitually consuming high flavonoid intakes, but data from human intervention studies is sparse. We therefore investigated whether 12 weeks of blueberry concentrate supplementation improved cognitive function in healthy elderly via increased brain activation and perfusion.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-10
• Primary Completion: 2014-09
• Study Completion: 2014-09
• Status Verified: 2016-09
• Study First Submitted: 2016-09-13
• Study First Submitted QC: 2016-12-02
• Last Update Submitted: 2016-12-02
• Study First Posted: 2016-12-07
• Last Update Posted: 2016-12-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• aged 60-80y
• Addenbrooke's Cognitive Examination III questionnaire > 88
• Consuming 5 or less portions of fruit per day

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Exclusion Criteria

Addenbrooke's Cognitive Examination III questionnaire < 88 Contraindications for MRI Consuming more than 5 portions of fruit per day

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Blueberry	Blueberry	Blueberry concentrate consumed daily for 12 weeks.
Placebo	Placebo	Placebo concentrate consumed daily for 12 weeks.

Primary Outcome Measures

Name	Time	Method
Brain perfusion	Change from baseline to 12 weeks dietary supplementation	MRI - arterial spin labelling

Secondary Outcome Measures

Name	Time	Method
Cognitive function tests	Change from baseline to 12 weeks dietary supplementation	Cogstate battery of tests
Brain activation	Change from baseline to 12 weeks dietary supplementation	fMRI whilst performing modified Stroop task
Blood biomarkers of inflammation	Change from baseline to 12 weeks dietary supplementation	CRP, IL6,
Blood biomarkers of oxidative stress	Change from baseline to 12 weeks dietary supplementation	protein carbonyls, glutathione
Blood biomarkers of neurogenesis	Change from baseline to 12 weeks dietary supplementation	BDNF