Motor Imagery Intervention for Improving Gait and Cognition in the Elderly
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 49
- 试验地点
- 2
- 主要终点
- Change in Walking Speed During Single and Dual-task Walking Conditions
研究概览
简要总结
The investigators propose a single-blind randomized clinical trial to determine if seniors show improved mobility (walking speed) and cognition following motor imagery (imagined walking) training. They hypothesize that imagined walking can be used as a rehabilitative tool for improving walking speed and cognition in the elderly, because it engages and strengthens similar neural systems as actual walking and cognition.
详细描述
The proposed research aims to establish the efficacy of an imagined gait protocol for improving gait and cognition in the elderly. This imagined gait protocol involves imagined gait in single (imagined walking; iW) and dual-task (imagined walking while talking; iWWT) situations. A single-blind randomized clinical trial of 58 cognitively-healthy elderly with pre-post measures of gait, cognition, and functional Magnetic Resonance Imaging (fMRI) during imagined gait is proposed. The overall hypothesis is that imagined gait can be used as a rehabilitative tool for improving gait and cognition in the elderly because it engages and strengthens similar neural systems as actual gait and cognition. The first aim of this study is to establish the efficacy of our imagined gait protocol to improve gait and cognition in the elderly. We predict that our imagined gait intervention will improve gait velocity during actual walking and walking-while-talking conditions to a greater extent than the active control (visual imagery) intervention. We also predict that our imagined gait intervention will cognitive performance during dual-task walking conditions. The second aim of this study is to determine neuroplasticity changes in response to our imagined gait protocol. We predict that the neural systems engaged during imagined gait will change following our imagined gait intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 65 Years 至 85 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults between 65 and 85 years and older, residing in the community.
- •Able to speak English at a level sufficient to undergo study procedures.
- •Plan to be in the area for the next 3 months.
排除标准
- •Presence of dementia (telephone-based memory impairment screen < 5 or Ascertain Dementia 8-item Informant Questionnaire score > 1)
- •Presence of gait disorder diagnosed by clinician (e.g. neuropathy).
- •Any medical condition or chronic medication use (e.g. neuroleptics) that will compromise safety or affect cognitive functioning.
- •Terminal illness with life expectancy <12 months.
- •Progressive, degenerative neurologic disease (e.g. Parkinson's disease, ALS).
- •Major psychiatric disorders such as Schizophrenia.
- •Pacemaker or any permanent metal implants like hip prosthesis (other than tooth fillings) and claustrophobia.
结局指标
主要结局
Change in Walking Speed During Single and Dual-task Walking Conditions
时间窗: Baseline and 3 months
Change in gait speed (centimeters per second) measured during normal pace walking and walking while talking conditions using an instrumented pathway. A positive mean value is indicative of an improvement (increase) in gait speed post-intervention, whereas a negative mean value is indicative of a decrease in gait speed post-intervention.
次要结局
- Change in Letter Number Sequencing Task Score(Baseline and 3 months)
- Change in Gait Variability(Baseline and 3 months)
- Change in Blood-oxygen-level-dependent (BOLD) Signal During Dual-task Imagined Walking While Talking (iWWT) Conditions(Baseline and 3 months)
- Change in Trail Making Test Form B(Baseline and 3 months)
- Change in Trail Making Test Form B Minus Form A(Baseline and 3 months)
- Change in Cognitive Performance During Walking While Talking(Baseline and 3 months)
- Change in Stroop Interference Test: Color-Word Minus Color Score(Baseline and 3 months)
- Change in Flanker Interference Task(Baseline and 3 months)
- Change in Gait Domains(Baseline and 3 months)
- Change in Trail Making Test Form A(Baseline and 3 months)
- Change in Stride Length(Baseline and 3 months)