Epigenetic Mechanisms linking Pre-conceptional nutrition and Health Assessed in India and Sub-Saharan Africa

niversity of Southampton0 个研究点目标入组 293 人开始时间: 2017年5月18日最近更新: 2023年6月26日

适应症

试验速览

2017 Protocol article in https://pubmed.ncbi.nlm.nih.gov/30820326/ protocol (added 30/06/2020) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32889533/ results (added 08/09/2020) 2022 Results article in https://doi.org/10.1186/s13148-021-01213-3 (added 15/06/2023)

•1. Healthy children aged five to seven years participating in the SARAS KIDS study (2013-2018) who were born as singleton live births to mothers who took part before and during pregnancy in the Mumbai Maternal Nutrition Project in India (http://www.isrctn.com/ISRCTN62811278) and who started supplementation at least 3 months prior to conception
•2. Healthy children aged five to seven years in the Gambia who were born as singleton live births to mothers who took part in the Peri-conceptional Multiple Micronutrient Supplementation Trial (http://www.isrctn.com/ISRCTN13687662) in the Gambia
•3. Parents consented to their participation in follow-up studies in which size, body composition, cardio-metabolic risk markers, cognitive function, and bone health were measured
•4. Consented to the use of their DNA samples for this research
•5. Samples contained sufficient DNA

•Children whose mothers took part in the Mumbai trial but who did not start supplementation at least 3 months before conception.

发起方

niversity of Southampton