NL-OMON40015
已完成
不适用
The ATACAS Trial: Aspirin and Tranexamic Acid for Coronary Artery Surgery Trial. A prospective, randomised, double blind, factorial trial testing whether aspirin, tranexamic acid, or both, can reduce mortality and/or major morbidity after elective coronary artery surgery. - ATACAS Trial
Alfred Hospital0 个研究点目标入组 29 人待定
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- CABG
- 发起方
- Alfred Hospital
- 入组人数
- 29
- 状态
- 已完成
- 最后更新
- 2年前
概览
简要总结
Trial is onging in other countries
研究者
入排标准
入选标准
- •1\. Males and females, age 18 years and over
- •2\. Written, informed consent
- •3\. Elective coronary artery surgery (on\-pump or off\-pump)
- •4\. Patient is at increased risk of major complications, defined by any of:
- •\* Age 70 years and over
- •\* Left ventricular impairment (fractional area change \<20%, ejection fraction \<40%, or at least moderate impairment on ventriculography)
- •\* Concomitant valvular or aortic surgery
- •\* Aneurysmectomy
- •\* Repeat cardiac surgery (\*re\-do\*)
- •\* Chronic obstructive pulmonary disease
排除标准
- •1\. Poor (Dutch) language comprehension
- •2\. Clinician preference for antifibrinolytic therapy
- •3\. Urgent surgery for unstable coronary syndromes where for clinical reasons antiplatelet medication cannot be discontinued
- •4\. Active peptic ulceration
- •5\. Allergy or contraindication to aspirin or tranexamic acid
- •6\. Aspirin therapy within 4 days of surgery
- •7\. Warfarin or clopidogrel therapy within 7 days of surgery, or GIIb/IIIa antagonists within 24 h of surgery
- •8\. Thrombocytopaenia or any other known history of bleeding disorder
- •9\. Severe renal impairment (serum creatinine \>250 \*mol/l, or estimated creatinine clearance \<25 ml/min)
- •10\. Recent haematuria
结局指标
主要结局
未指定
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