Impact of Highest Drain Fluid Amylase Levels on Surgical Outcomes and Postoperative Interventions in Patients Undergoing Pancreaticoduodenectomy
- Conditions
- Pancreas; Fistula
- Registration Number
- NCT04448795
- Lead Sponsor
- Chang Gung Memorial Hospital
- Brief Summary
This study investigated the impact of highest drain fluid amylase (DFA) level on postoperative pancreatic fistula (POPF) severity and outcomes of patients undergoing pancreaticoduodenectomy (PD) with POPF. Patient demographics of biochemical POPF and clinically relevant POPF (CR-POPF) were compared. Predictive factors were assessed using binary logistic regression. Receiver operating characteristic curve analysis was performed to determine the optimal cutoff value of highest DFA (beyond 3 days post-PD). The investigators compared length of hospital stay, surgical mortality rates, and need for postoperative interventions by highest DFA level.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 600
- underwent PD from October 2010 to September 2018 in our institution
- younger than 20 years of age
- clinical information was unavailable due to private or legal issues
- receiving PD without pancreaticojejunostomy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method postoperative pancreatic fistula through study completion, an average of 2 month fluid output of any measureable volume via an operatively placed drain with amylase activity greater than 3 times the upper normal serum value
- Secondary Outcome Measures
Name Time Method length of hospital stay through study completion, an average of 2 month 30-day mortality rates 30 day postoperative interventions through study completion, an average of 2 month transarterial embolization, image-guided second drainage, and reoperation