Randomized control study comparing reconstruction procedures after esophagectomy -gastric tube reconstruction vs gastric tube reconstruction with duodenal diversion plus Roux-en Y anastomosis
- Conditions
- Patients with resectable thoracic esophageal cancer who are planned to undergo esophagectomy with gastric tube reconstruction and 2 or 3 field lymphadenectomy
- Registration Number
- JPRN-UMIN000016949
- Lead Sponsor
- Osaka Medical Center for Cancer and Cardiovascular Diseases
- Brief Summary
Operation time and blood loss volume were higher in the RY group. Pancreatic amylase concentrations in the gastric conduit were higher in the non-RY group. Endoscopic examination showed residual gastric content in 7/17 patients in the non-RY group but in none in the RY group. QOL was significantly favorable in the RY group with regard to reflux symptoms and food passage dysfunction. Body weight changes, serum albumin levels, and peripheral blood lymphocyte counts were not significantly different.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 60
Not provided
1. synchronous other malignant cancer within 1 year 2. Miocardial infarction, Master two steppositive on ECG 3. preoperative respiratory test, FEV1.0 is less than 50% 4. prior chemotherapy or radiationtherapy within 6 months 5. prior gastric or intestinal resection 6. severe absorptive disturbance 7. severe postoperative complications (anastomotic leakage, ileus, intraabdominal abcess, pneumonia, etc) 8. pregnant 9. other severe co-morbidities 10. In case where surgeon judge that entry to the study is impossible.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method