The Significance of Latissimus Dorsi Flap Innervation in Delayed Breast Reconstruction

Phase 3

Completed

• Conditions: Significance of Latissimus Dorsi Flap Innervation in Delayed Breast Reconstruction
• Interventions: Procedure: denervation of thoracodorsal nerve or saving the nerve

• Registration Number: NCT01239524
• Lead Sponsor: Tampere University Hospital

Brief Summary

Breast reconstruction with a pedicled myocutaneous latissimus dorsi (LD) flap is a widely used reconstruction method. It is controversial if surgical denervation by transecting the thoracodorsal nerve should be performed or not. It is assumed that after denervation the latissimus dorsi muscle will significantly atrophy and lose volume. On the other hand discomforting signs and symptoms from muscle contraction are believed to be prevented if flap is denervated. The aim of the study was prospectively evaluate the influence of LD-flap innervation on the functional and aesthetic outcome of delayed breast reconstruction, and to compare the change in muscle structure in breast MRI and histopathology.

Detailed Description

Not available

Study Timeline

• Status Verified: 2010-11
• Study First Submitted: 2010-11-10
• Study First Submitted QC: 2010-11-10
• Last Update Submitted: 2010-11-10
• Study First Posted: 2010-11-11
• Last Update Posted: 2010-11-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 28

Inclusion Criteria

• delayed LD-flap breast reconstruction, no recurrent disease observed

Exclusion Criteria

• recurrent cancer, partial resection of the breast

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
DE-group	denervation of thoracodorsal nerve or saving the nerve	surgical denervation by excising 1 cm of proximal thoracodorsal nerve
IN group	denervation of thoracodorsal nerve or saving the nerve	thoracodorsal nerve is saved intact