Polymorphids and mRNA Expression in Genes, Significant for Developing Obesity and Typ II Diabetes in Different Types/Localisations of Fat Tissue
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Differences in polymorphids and/or mRNA expression in genes, significant for developing obesity and type 2 diabetes, between patients with normal weight and obesity
研究概览
简要总结
Fat tissue from omenta, thigh and abdomen taken under anesthesia on subjects undergoing laparoscopic surgery, cholecystectomy, reflux surgery or gastric by-pass (GBP).
Are there any difference in polymorphids and/or mRNA expression in genes significant for developing obesity, between normal weight and obese individuals, with or without diabetes typ 2 .
Are there any difference in polymorphids and/or mRNA expression in different types of fat tissue
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 18 years or older
- •laparoscopic surgery (Gastric by-pass, cholecystectomy, antireflux surgery)
- •Normal weight without type 2 diabetes BMI 18-25
- •Obese without type 2 diabetes BMI>35
- •Obese with type 2 diabetes BMI>35
排除标准
- •under 18 years
- •open surgery
- •pregnancy
- •BMI >27-<35
结局指标
主要结局
Differences in polymorphids and/or mRNA expression in genes, significant for developing obesity and type 2 diabetes, between patients with normal weight and obesity
时间窗: approximatly 30 minutes after start of operation
fat biopsy taken from abdomen, omenta and thigh at surgery
Difference in polymorphids and/or mRNA expression in different types of fat tissue in patients with normal weight or obesity with or without diabetes type 2
时间窗: approximatly 30 minutes after start of operation
fat biopsy; abdomen, omenta and thigh taken at surgery
次要结局
未报告次要终点
研究者
Anders Thorell
Associated professor, MD
Karolinska Institutet