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临床试验/NCT02383537
NCT02383537Unknown不适用

Biological Changes in the Adipose Tissue (RNA Profile) Among Pregnant Women With Diabetes

Hadassah Medical Organization0 个研究点目标入组 150 人开始时间: 2017年4月最近更新:
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适应症

试验速览

阶段
不适用
入组人数
150
主要终点
miRNA profiling
研究概览研究设计入排标准结局指标研究者记录与标识符相似试验

研究概览

简要总结

The aim of the research is to study the effect of miRNA, fat tissue and insulin resistance on the pathophysiology of diabetes during pregnancy. During the study fat tissue, Umbilical cord blood, placenta tissue and subcutaneous fat will be taken from pregnant diabetic woman over going a C-section. Healthy pregnant women will serve as a control group.

详细描述

The aim of the research is to study the effect of miRNA, fat tissue and insulin resistance on the pathophysiology of diabetes during pregnancy. During the study:

  1. fat tissue, Umbilical cord blood, placenta tissue and subcutaneous fat will be taken from pregnant diabetic woman over going a C-section.
  2. Bloods will be analyzed for insulin, c-peptide, glucose and fat profile
  3. Placenta and fat tissue will be analyzed for miRNA and total RNA
  4. Clinical and anthropometric measurements will be taken from the mother
  5. Placenta status will be taken

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
18 Years 至 45 Years（Adult）
性别
Female
接受健康志愿者
是

入选标准

  • •age 18-45
  • •signed consent form
  • •going through an elective C-section
  • •reference group: healthy women with no background illness

排除标准

  • •<18 or >45
  • •chronic illness that may effect the outcome
  • •polypharmacy

结局指标

主要结局

miRNA profiling

时间窗: samles are taken during C-section samples will be analyzed after completion of collection

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

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