Biological Changes in the Adipose Tissue (RNA Profile) Among Pregnant Women With Diabetes
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pregnancy
- Sponsor
- Hadassah Medical Organization
- Enrollment
- 150
- Primary Endpoint
- miRNA profiling
- Last Updated
- 9 years ago
Overview
Brief Summary
The aim of the research is to study the effect of miRNA, fat tissue and insulin resistance on the pathophysiology of diabetes during pregnancy. During the study fat tissue, Umbilical cord blood, placenta tissue and subcutaneous fat will be taken from pregnant diabetic woman over going a C-section. Healthy pregnant women will serve as a control group.
Detailed Description
The aim of the research is to study the effect of miRNA, fat tissue and insulin resistance on the pathophysiology of diabetes during pregnancy. During the study: 1. fat tissue, Umbilical cord blood, placenta tissue and subcutaneous fat will be taken from pregnant diabetic woman over going a C-section. 2. Bloods will be analyzed for insulin, c-peptide, glucose and fat profile 3. Placenta and fat tissue will be analyzed for miRNA and total RNA 4. Clinical and anthropometric measurements will be taken from the mother 5. Placenta status will be taken
Investigators
Eligibility Criteria
Inclusion Criteria
- •age 18-45
- •signed consent form
- •going through an elective C-section
- •reference group: healthy women with no background illness
Exclusion Criteria
- •\<18 or \>45
- •chronic illness that may effect the outcome
- •polypharmacy
Outcomes
Primary Outcomes
miRNA profiling
Time Frame: samles are taken during C-section samples will be analyzed after completion of collection