Identification of Novel Targets for Regulation of Adipose Tissue Mass
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obesity
- Sponsor
- Gottfried Rudofsky
- Enrollment
- 62
- Locations
- 1
- Primary Endpoint
- number of adipocytes and preadipocytes under weight loss
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
The aim of this study is to understand the metabolic changes occurring in fat tissue both during controlled weight loss that lead to the improvement of type 2 diabetes and other obesity associated metabolic disorders. The novelty of the study is the analysis of preadipocytes, a poorly characterized subfraction of the adipose tissue, which provides adipocyte precursors and thereby strongly influences adipose tissue mass changes. Knowledge of pathways involved in controlling adipose tissue composition will help to design novel intervention strategies for the treatment of obesity associated metabolic disorders such as type 2 diabetes.
Investigators
Gottfried Rudofsky
Oberarzt
Heidelberg University
Eligibility Criteria
Inclusion Criteria
- •Participants of the OPTIFAST52 program
- •BMI \> 30 kg/m2
Exclusion Criteria
- •Rejection of informed consent by the participant
Outcomes
Primary Outcomes
number of adipocytes and preadipocytes under weight loss
Time Frame: three years
Secondary Outcomes
- metabolic function of adipocytes and preadipocytes under weight loss(three years)