Comparation Analgesia Efficiency With Propofol Combine Sevoflurane vs Propofol Using Index of Nociception (NOX)
Overview
- Phase
- Phase 3
- Intervention
- 5mg/kg/h Propofol
- Conditions
- Nociceptive Pain
- Sponsor
- China International Neuroscience Institution
- Enrollment
- 146
- Locations
- 1
- Primary Endpoint
- qNOX change
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
This study purpose to compare analgesia efficiency of propofol combine with sevoflurane with propofol only using index of Nociception (NOX)
Detailed Description
1. Recently study found sevoflurane plays an important role through spinal nerve peptide receptor (NK.1R), glycine receptor (GlyR), neuron nicotinic receptor (nnAChRs), Methyl-1-methyl-1-day aspartate (NMDA receptor), and TRPV1 receptor (TRPV1 receptor) produce the analgesic efficiency. 2. propofol was traditional sedation reagent. 3. index of Nociception (NOX) was the objective index for analgesia This study purpose to compare analgesia efficiency of Only Propofol and sevoflurane combine with propofol using index of Nociception (NOX)
Investigators
Eligibility Criteria
Inclusion Criteria
- •Participants were aged 18-65 years old,
- •American Society of Anesthesiologists (ASA) physical status I, II or III
- •scheduled to have urological surgery(would last longer than 1 h)
- •requiring general anesthesia.
- •Exclusion criteria:
- •refused to participate in this study;
- •Unable to communicate normally because of consciousness alterations;
- •a history of allergy to opioids
- •contraindications to inhalational anesthesia
- •a family history of malignant hyperthermia
Exclusion Criteria
- Not provided
Arms & Interventions
Propofol
5mg/kg/h Propofol continue infusion during the maintain of anesthesia during the maintain of anesthesia.
Intervention: 5mg/kg/h Propofol
Propofol & Sevoflurane
2mg/kg/h Propofol \& 1% Sevoflurane group continue infusion(Balance anesthesia) during the maintain of anesthesia
Intervention: Sevoflurane
Propofol & Sevoflurane
2mg/kg/h Propofol \& 1% Sevoflurane group continue infusion(Balance anesthesia) during the maintain of anesthesia
Intervention: 2 mg/kg/h Propofol
Outcomes
Primary Outcomes
qNOX change
Time Frame: during operation
Nociception of index (qNOX) difference between two groups. The nociception index (NOX) derived from electroencephalogram (EEG) signals has been proposed as a noninvasive guide to indicate anesthesia depth. The neurological processing of noxious stimuli is defined as nociception. NOX ranges from 0-99, and the lower the index, the deeper the state of analgesia. NOX lower than 20 represents deep analgesia, and higher than 80 represents inadequate analgesia.
Secondary Outcomes
- PACU duration(24 hours)
- PONV difference between two groups(24 hours)
- Post- operative pain difference between two groups(24 hours)