Depression Prevention Initiative - A Study of Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST) in School Settings
- Conditions
- Depression
- Interventions
- Behavioral: IPT-ASTBehavioral: Group Counseling
- Registration Number
- NCT01201382
- Lead Sponsor
- Children's Hospital of Philadelphia
- Brief Summary
This study is a randomized controlled trial comparing Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST) to group counseling (GC) for the prevention of depression in adolescents. The project will: (1) identify adolescents with elevated depressive symptoms but who do not meet criteria for a current mood disorder diagnosis; (2) randomize eligible adolescents to either IPT-AST (N = 100) or GC (N = 100); (3) assess depressive symptoms, depressive disorders, global functioning, interpersonal functioning, comorbid conditions and school related indices at baseline, mid-intervention, post-intervention, and at 6-, 12-, 18-, and 24-month follow-up; (4) examine the effects of IPT-AST on depression and various domains of functioning at each time point; and (5) conduct analyses to examine potential mediators and moderators of the association between IPT-AST and depression outcomes. This study will yield data on the efficacy of IPT-AST relative to GC for the prevention of depressive symptoms and depressive disorders. It will also provide information about the mechanisms of action of IPT-AST and determine for whom IPT-AST is most effective.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 185
- In 7th-10th grades at intake
- Center for Epidemiologic Studies Depression Scale(CES-D) Score > 16
- At least 2 symptoms on the K-SADS depression section (score of 2 or 3), one of which is either depressed mood, irritability, or anhedonia
- Adolescent must be English-speaking
- Parent speaks English or Spanish
- CES-D Score < 15
- Fewer than 2 depression symptoms on the K-SADS (score of 2 or 3) or 2 or more symptoms on the K-SADS with no report of depressed mood, irritability, or anhedonia
- Suicide attempt or self-mutilation in the past year, current active suicidal ideation, and/or history of a clinically significant suicidal behavior (i.e., with intent to die and high medical lethality) or repeated patterns of self-injurious behavior
- Presence of current Major Depressive Disorder, dysthymia, substance abuse, schizophrenia, bipolar disorder, conduct disorder, or psychosis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description IPT-AST IPT-AST Interpersonal Psychotherapy-Adolescent Skills Training Group Counseling Group Counseling Group Counseling
- Primary Outcome Measures
Name Time Method Presence of a Major Depressive Episode, Dysthymia or Depressive Disorder Not Otherwise Specified (NOS) on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL) Post intervention (approximately 3 months post baseline) Presence of a depression diagnosis as measured by a semi-structured diagnostic evaluation
Presence of a Major Depressive Episode, Dysthymia or Depressive Disorder NOS on the K-SADS-PL 24-months post-intervention
- Secondary Outcome Measures
Name Time Method Children's Depression Rating Scale-Revised (CDRS-R) Post intervention (approximately 3 months after baseline) Scores on the CDRS-R
Children's Depression Rating Scale-Revised 24 months post-intervention Children's Global Assessment Scale (CGAS) Post intervention (approximately 3 months following baseline) Assesses global functioning
Children's Global Assessment Scale 24-months post-intervention
Trial Locations
- Locations (2)
Rutgers University
🇺🇸Piscataway, New Jersey, United States
Children's Hospital of Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States