Post-Caesarean Section Incisional Infiltration With Lidocaine Versus Lidocaine and Epinephrine
Phase 4
Completed
- Conditions
- Pain, Postoperative
- Interventions
- Registration Number
- NCT02274974
- Lead Sponsor
- Ain Shams Maternity Hospital
- Brief Summary
Study to compare between efficacy of post-caesarean section infiltration with lidocaine and epinephrine versus lidocaine only to reduce post-incisional pain.
- Detailed Description
assessment of adding of epinephrine to lidocaine as local infiltrator to post-caesarean section wound in prolongation of its anaesthetic effect.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 160
Inclusion Criteria
- Women undergoing caesarean delivery under General anesthesia for various indications.
- Women refuse spinal anesthesia.
Exclusion Criteria
- Known or suspected sensitivity to local anesthesia.
- Medical disorders induced by pregnancy (Pre-eclamptic toxemia, gestational diabetes mellitus, Hepatic diseases, homeostatic disorder)
- Medical disorders aggravated by pregnancy (cardiovascular disease, pulmonary disease, renal disease, neurological disease, metabolic or infectious diseases).
- Women who hemo-dynamically unstable.
- Lack of adequate verbal communication.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description lidocaine Lidocaine 20 ml of 2% lidocaine. lidocaine and epinephrine. lidocaine and Epinephrine 20 ml of 2% lidocaine and epinephrine in related dose manner 1:200.000. I.e.: by adding 1/4 from ampoule of adrenaline 1mg./1ml to bottle of lidocaine Hydrochloric acid (HCL) 2% 50 ml(20mg/ml).
- Primary Outcome Measures
Name Time Method Timing of first analgesic request. 24 hours
- Secondary Outcome Measures
Name Time Method Side effects of local infiltration of lidocaine and epinephrine 7 days Postoperative pyrexia 24 hours \<38°c
Duration of cesarean section 30 min to 90 min Onset of mobilization 24 hours first time patient start moving after the section
Onset of breast breastfeeding 24 hours Duration of hospital stay 24 hours to 48 hours
Trial Locations
- Locations (1)
Post-Caesarean Section Incisional Infiltration With Lidocaine Versus Lidocaine and Epinephrine;
🇪🇬Cairo, Egypt