Effects of Navigated Repetitive Transcranial Magnetic Stimulation According to Post-stroke Aphasia Types

Not Applicable

Completed

• Conditions: To Healthy Volunteer; Virtual Lesions for Aphasia
• Interventions: Device: Repetitive magnetic stimulation (Sham); Device: Repetitive magnetic stimulation to superior temporal gyrus; Device: Repetitive magnetic stimulation to middle temporal gyrus

• Registration Number: NCT01877161
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

Repetitive transcranial magnetic stimulation induced virtual lesions for aphasia.

Detailed Description

To evaluate the effect of navigated repetitive transcranial magnetic stimulation in subjects with aphasia after stroke.

Study Timeline

• Study Start: 2012-12
• Study First Submitted: 2013-03-11
• Primary Completion: 2013-05
• Study Completion: 2013-05
• Study First Submitted QC: 2013-06-10
• Study First Posted: 2013-06-13
• Results First Submitted: 2014-01-23
• Results First Submitted QC: 2014-05-20
• Results First Posted: 2014-06-04
• Status Verified: 2017-06
• Last Update Submitted: 2017-06-26
• Last Update Posted: 2017-07-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• fluent in Korean
• older than 18 years old

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Exclusion Criteria

• younger than 18 years old
• psychotic or psychiatric problems
• pregnant
• contraindications to MRI/fMRI
• uncooperative
• metalic implants, pacemaker or cochlear implants
• cannot perform outcome measure-related task
• known seizure history

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Control group	Repetitive magnetic stimulation (Sham)	Repetitive magnetic stimulation (Sham)
Superior temporal gyrus	Repetitive magnetic stimulation to superior temporal gyrus	Repetitive magnetic stimulation to superior temporal gyrus
Middle temporal gyrus	Repetitive magnetic stimulation to middle temporal gyrus	Repetitive magnetic stimulation to middle temporal gyrus

Primary Outcome Measures

Name	Time	Method
The Change of Reaction Time Between Before and After Stimulation in Each Session (MTG, STG, Sham)	change between before and after the TMS stimulation for each sessions (at session 1, session 2, session 3)	Reaction time for lexical and repetition test were measured before and after the TMS stimulation at each sessions (at session 1, session 2, session 3 over MTG/STG/Sham; MTG: middle temporal gyrus, STG: superior temporal gyrus).; Response times were measured via the response pad, and spoken responses were recorded via a SV-1 Voice Key apparatus.; The "reaction time post TMS - reaction time pre TMS" were used for analysis.\* Arm/Group Title Arm/Group Description Maximum length (999) Repetitive magnetic stimulation (rTMS) were applied over STG

Trial Locations

Locations (1)

Seoul National University Bundang Hospital; 🇰🇷 Seongnam-si, Bundang-gu, Korea, Republic of