Can Branched Chained Amino Acid Supplementation Combined With Strength-Training Minimize Sarcopenia in Older Men?
试验速览
- 阶段
- 不适用
- 状态
- 暂停
- 发起方
- 入组人数
- 6
- 试验地点
- 2
- 主要终点
- Required Branched chain amino acid of older strength trained men
研究概览
简要总结
Likely, branched chain amino acid (BCAA) requirements are increased in older strength-trained (ST) individuals. If so, supplementation in this group will maximize muscle protein synthesis (MPS) and minimize loss of muscle with age (sarcopenia).
详细描述
We hypothesize that the dietary requirement for the branched chain amino acids (BCAA) in an older strength-trained (ST) population will be greater than the current recommendation (RDA). If so, a greater intake of BCAA together with ST is necessary if one aims to maximize muscle protein synthesis (MPS). Currently, the BCAA requirement in the ST older population (55-65 y) is unknown. This is critical information especially given the value of ST for overall health.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 55 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Recreationally active (~2-3 h/wk of physical activity) healthy older men (55-65 y)
- •A minimum of 4 month weight training experience
排除标准
- •Have symptoms or take medication for respiratory disease
- •Have symptoms or take medication for cardiovascular disease
- •Have symptoms or take medication for metabolic disease
- •Have symptoms or take mediation for neuromuscular disease
- •Use heart rate or blood pressure medications
- •Use any medications with side effects of dizziness, lack of motor control, or slowed reaction time
- •Have an excessive alcohol intake (more than 2 drinks per day)
- •Have any cardiovascular or neuromuscular limitations to exercise
- •Are allergic to milk or milk products
- •Use anabolic steroids or performance enhancing drugs
结局指标
主要结局
Required Branched chain amino acid of older strength trained men
时间窗: 12 months
Branched chain amino acid requirement will be measured in 55-65 years old strength trained men using indicator amino acid oxidation method
次要结局
- Muscle size(12 months)
研究者
Peter Lemon
Professor and Weider Research Chair
University of Western Ontario, Canada