Stress and social cognition in cocaine users

Not Applicable

Completed

• Conditions: Cocaine use disorder; Mental and Behavioural Disorders; Mental and behavioural disorders due to use of cocaine

• Registration Number: ISRCTN10690316
• Lead Sponsor: Psychiatric Hospital of the University of Zurich

Brief Summary

2022 Results article in https://doi.org/10.1038/s41398-022-02204-5 (added 19/07/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-06-28
• Study Completion: 2020-07-31
• Last Update Posted: 2 August 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 123

Inclusion Criteria

General inclusion criteria:
1. To be able to read, understand and provide written informed consent
2. To be fluent in German
3. Women and men between the ages of 18 to 52 years
4. For women at baseline and follow up: not during menstruation phase

Specific inclusion criteria for cocaine users:
1. Estimated lifetime cocaine consumption >100 g
2. The abstinence duration from cocaine is <6 months
3. No regular use of opioids
4. No current polytoxic drug use pattern
5. No DSM-IV/5 Axis I adult psychiatric disorders — except for other substance use disorders (with exception of opioids), attention deficit hyperactivity disorder (ADHD), and a past depressive episode

Specific inclusion criteria for controls:
1. No DSM-IV/5 Axis I adult psychiatric disorders (except for tobacco use disorder)
2. No illegal drug use: less than 15 occasions and not during the last month (with the exception of cannabis)

Exclusion Criteria

1. Family history of genetic mediated (h2 > 0.5) psychiatric disorders according to DSM-IV/5
2. Presence of severe neurological disorder or brain injury
3. Current diagnoses of infectious diseases or severe somatic disorder
4. History of autoimmune, endocrine or rheumatoid arthritis
5. Intake of medication with potential action at central nervous system during the last three days
6. Participation in the Zurich Cocaine Cognition Study (KEK-Nr. E-14/2009)
7. For women: pregnancy or breastfeeding
8. Subjects can be excluded for matching reasons (age, sex, nicotine status)

Study & Design

• Study Type: Observational
• Study Design: Not specified