Are elevated prolactin levels harmful for the retinal and sublingual microvascular bed?

• Conditions: benign pituitary tumor; 10003216; pituitary adenoma; 10047060; 10021112

• Registration Number: NL-OMON32787
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

(For both patients as controls, with obviously exception of the first inclusion criteria)
Patients (both women and men) with active prolactinoma (either micro- or macroprolactinoma, with prolactin levels above >50 ng/ml
Age 20-60 years.
Written informed consent

Exclusion Criteria

(For both patients as controls)
Macroprolactinemie.
Infundibulum infiltration.
Diabetes mellitus type 2.
Pregnant women.
Premature atherosclerosis.
Use of antidepressive and antipsychotic medication.
Presence of co-morbidity that could affect retinal vasculature or its matrix.
History of hypersensitivity or allergy to fluorescein.
Inability to obtain SDF, fluorescein angiograms or OCT*s of sufficient quality to be analyzed and graded.
Active malignancy.
Systemic disease with a life expectancy shorter than the duration of the study.
Inability to adhere to the protocol with regard to injection and visits.
Legally incompetent adult.
Refusal to give written informed consent.
Additional use of medication that could affect neo-angiogenesis.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified