The Potential Role of Testosterone on Target Organ Damage in Postmenopausal Hypertensive Women
- Conditions
- Hypertension
- Registration Number
- NCT03451747
- Lead Sponsor
- LanZhou University
- Brief Summary
The incidence of CVD-related deaths is generally higher in women than men. Postmenopausal changes in estrogen/androgen ratio that induce a relative androgen excess have been proposed as important factors in the higher prevalence of hypertension. Therefore, the investigators hypothesize that testosterone has potential role between hypertension and target organ damage in postmenopausal hypertensive women. And the objective is to evaluate the effects of testosterone between hypertension and target organ damage in postmenopausal hypertensive women.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 322
- Clinical diagnosis of hypertension
- Women are all postmenopausal
- Men are matched with women.
- Secondary hypertension
- Coronary disease
- Heart failure
- Arterial fibrillation
- Previous myocardial infarction
- Previous stroke
- Malignant disease
- Kidney failure
- Liver failure
- Neoplastic disease
- Severe neurological diseases
- Severe metabolic or organic decompensation
- Refuse to sign the informed consent form
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Relative indexes of myocardial remodeling Baseline Cardiac structure (left ventricular mass index in grams for square meter) measurement.
The level of testosterone (T) Baseline Blood samples used to analyze the levels of sexual hormones were collected between morning 8:00 and 9:00 after an overnight fast. Testosterone (T) units on nanogram per deciliter.
Ambulatory blood pressure monitoring Baseline Non-invasive ambulatory blood pressure monitoring (ABPM) was performed for every enrolled patient with an ABPM equipment.
- Secondary Outcome Measures
Name Time Method