The Application of Fluorescence Laparoscopy in the Treatment of Adenocarcinoma of the Esophagogastric Junction
Not Applicable
- Conditions
- Adenocarcinoma of the Esophagogastric JunctionFluorescence Laparoscopy
- Interventions
- Procedure: fluorescent laparoscopic radical gastrectomyProcedure: traditional laparoscopic radical gastrectomy
- Registration Number
- NCT03647540
- Lead Sponsor
- Dong Yang
- Brief Summary
The fluorescent laparoscopic technique would be applied to the radical resection of gastric cancer at the junction of esophagus and stomach, and compared with the traditional laparoscopic radical resection of gastric cancer to find a better surgical method for patients
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 164
Inclusion Criteria
-
- All cases should be diagnosed as adenocarcinoma of the esophagogastric junctionncer by histology. The tumor is within 1 cm above or 2 cm below the anatomic cardia. The clinical stage is T1-3, Nx, M0 for gastric cancer which can undergo the laparoscopic surgery.
- Eastern Cooperative Oncology Group (ECOG) scale 0-2 3. Heart, lung, liver, and kidney function can tolerate operation 4. Patients and their families are able to understand and be willing to participate in this clinical study and to sign informed consent.
Exclusion Criteria
- history of stomach malignant disease 2. recent diagnosis of other malignant tumors (except for papillary carcinoma of the thyroid gland and basal cell carcinoma of the skin) 3. patients with obstruction, perforation, bleeding requiring emergency surgery 4. a history of abdominal surgery (which makes it difficult to perform laparoscopic procedures), severe systemic disease such as diabetes, severe chronic lung disease, cirrhosis, other malignant diseases 5. combined stomach multiple carcinomas 6. with a history of serious mental illness 7. pregnant or lactating women 8. The researchers believe that the patients are unsuitable to participate in the researchers with other cases.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group F fluorescent laparoscopic radical gastrectomy Group F received endoscopic submucosal injection of indocyanine green (ICG) 2 hours before operation, followed by fluorescent laparoscopic radical gastrectomy. All specimens were grouped for lymph node collection, and the postoperative management was unified according to enhanced recovery after surgery (ERAS). All basic clinical and pathological data were statistically analyzed Group L traditional laparoscopic radical gastrectomy Group L received traditional laparoscopic radical gastrectomy. All specimens were grouped for lymph node collection, and the postoperative management was unified according to enhanced recovery after surgery (ERAS). All basic clinical and pathological data were statistically analyzed
- Primary Outcome Measures
Name Time Method the number of the dissected lymph nodes in the perioperative period It includes the total number of the dissected lymph nodes and every group of lymph nodes
- Secondary Outcome Measures
Name Time Method 3-year disease-free survival three years after operation] cases converted to open surgery in the perioperative period the operation time in the perioperative period The descriptive name of unit would be minute (min).
the incidence of complications one month after surgery the blood loss during the operation in the perioperative period The descriptive name of unit would be millilitre (ml).
Postoperative recovery of intestinal peristalsis in the perioperative period The descriptive name of unit would be hour (h).
The mean postoperative hospital stay in the perioperative period The descriptive name of unit would be day (d).
Trial Locations
- Locations (1)
the First Hospital of Jilin University
🇨🇳Ch'ang-ch'un, Ji Lin, China