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Clinical Trials/NCT04938661
NCT04938661
Completed
N/A

Improving Cardiac Rehabilitation Outcomes Through Mobile Case Management (iCARE)

Mayo Clinic4 sites in 1 country206 target enrollmentJuly 8, 2021

Overview

Phase
N/A
Intervention
Center-Based Cardiac Rehab
Conditions
Acute Myocardial Infarction
Sponsor
Mayo Clinic
Enrollment
206
Locations
4
Primary Endpoint
Number of participants who are re-hospitalized during the trial
Status
Completed
Last Updated
5 days ago

Overview

Brief Summary

The purpose of this research is to find out if doing cardiac rehab at home, or a mix of cardiac rehab at home and in the clinic, is as effective as coming in to the clinic for cardiac rehab.

Detailed Description

To address our specific aims we will use a single-center, prospective, three-arm, parallel group, randomized controlled trial design. At the time of identification of eligibility for participation, patients will be randomized to one of three arms (1:1:1 ratio): Arm 1 consists of patients randomized to conventional cardiac rehab only, Arm 2 consists of patients randomized to conventional cardiac rehab with the addition of the mHealth platform, and Arm 3 consists of patients randomized to remote case management using the mHealth platform only. Clinical metrics will include traditional cardiovascular risk factors with additional tracking of service utilization and adherence, and quality of life. Measures will be made at baseline (pre-intervention) and \~3-months (coinciding with completion of conventional CR). Additional follow-up will occur at 12 months post CR entry. Randomization to study arms will be done with a multidimensional dynamic allocation algorithm, minimizing imbalances in age, sex, body mass index, and race across study arms.

Registry
clinicaltrials.gov
Start Date
July 8, 2021
End Date
June 9, 2025
Last Updated
5 days ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Thomas P. Olson, M.S., Ph.D.

Associate Professor of Medicine

Mayo Clinic

Eligibility Criteria

Inclusion Criteria

  • Own or have reliable access to a smartphone or desktop computer with internet access
  • Have an email address
  • Patients who have a history of one of the following; acute myocardial infarction/acute coronary syndrome, stable angina pectoris, percutaneous coronary intervention, or heart failure.
  • Patients who have undergone a surgical procedure which includes an indication for cardiac rehabilitation (coronary artery bypass surgery, heart valve repair/replacement, or heart transplant)

Exclusion Criteria

  • Patients referred to cardiac rehab with ventricular assist devices.

Arms & Interventions

Conventional Center-Based Cardiac Rehab (CON)

Participants will be prescribed 36 sessions of center-based CR. This includes supervised exercise sessions, cooking demonstrations, didactic lectures, video presentations, group support, and stress management education. During sessions, participants have direct access to the medical director, case manager, registered nurse, exercise physiologist, and stress management specialists.

Intervention: Center-Based Cardiac Rehab

Conventional Center-Based Cardiac Rehab + mHealth (CON+)

Participants will be prescribed 36 sessions of center-based CR as noted above. In addition, participants will be provided access to the mHealth platform which provides "e-Learning modules" with factsheets, videos, quizzes, and questionnaires (coinciding with activities being conducted during the CON program), a Social Network Module will allow patients to communicate via secure network with other patients who are part of their invited network. The Social Network Module also allows for secure two-way interaction with healthcare providers in the event that patients are experiencing signs or symptoms suggestive of worsening condition. This platform also contains a Personal Health Record Module allowing patients to upload, archive, and retrieve personal health data (e.g. fitness tracker data, heart rate monitor data, blood pressure recordings, etc.) and record vital signs, symptoms, treatments, and medical history.

Intervention: Center-Based Cardiac Rehab

Conventional Center-Based Cardiac Rehab + mHealth (CON+)

Participants will be prescribed 36 sessions of center-based CR as noted above. In addition, participants will be provided access to the mHealth platform which provides "e-Learning modules" with factsheets, videos, quizzes, and questionnaires (coinciding with activities being conducted during the CON program), a Social Network Module will allow patients to communicate via secure network with other patients who are part of their invited network. The Social Network Module also allows for secure two-way interaction with healthcare providers in the event that patients are experiencing signs or symptoms suggestive of worsening condition. This platform also contains a Personal Health Record Module allowing patients to upload, archive, and retrieve personal health data (e.g. fitness tracker data, heart rate monitor data, blood pressure recordings, etc.) and record vital signs, symptoms, treatments, and medical history.

Intervention: mHealth

Home-Based Cardiac Rehab + mHealth (HOM+)

Participants will be provided paper copies of educational content at the time of event/discharge. In addition, these participants will be provided access to the same mHealth platform as the CON+ group. Participants in this group will be encouraged to exercise three days per week while also completing the additional questionnaires and educational content provided by the mHealth platform in accordance with the CR program. Participation will be tracked using web/internet analytics.

Intervention: mHealth

Home-Based Cardiac Rehab + mHealth (HOM+)

Participants will be provided paper copies of educational content at the time of event/discharge. In addition, these participants will be provided access to the same mHealth platform as the CON+ group. Participants in this group will be encouraged to exercise three days per week while also completing the additional questionnaires and educational content provided by the mHealth platform in accordance with the CR program. Participation will be tracked using web/internet analytics.

Intervention: Home-Based Cardiac Rehab

Outcomes

Primary Outcomes

Number of participants who are re-hospitalized during the trial

Time Frame: 1 Year

We will look at the number of patients who are hospitalized for any reason during the follow-up period

Functional Capacity

Time Frame: 3 Months

VO2 peak

Change in Metabolic Equivalents of Task (METS)

Time Frame: Baseline; 3 Months

The change in metabolic equivalents of task (METS) assessed by measuring the energy the body uses during activity relative to resting energy expenditure.

Number of Participants Who Were Re-hospitalized During the Trial

Time Frame: 1 Year

The number of participants who were re-hospitalized during the trial.

Adherence to the Intervention

Time Frame: Baseline to 3 Months

The percentage of completed visits per participant that were attended from the start of the intervention (baseline) to the end of the intervention (3 months) relative to the number of prescribed visits per participant.

Secondary Outcomes

  • Fasting Blood Glucose(3 Months)
  • Fasting Hemoglobin(3 Months)
  • Fasting Hemoglobin A1C(3 Months)
  • Fasting Basic Lipid Panel(3 Months)
  • Self-Reported Quality of Life(3 Months)
  • 6 Minute Walk Test(3 Months)
  • Self-Reported Physical Activity(3 Months)
  • Self-Reported Dietary Patterns(3 Months)
  • Change in Body Weight(3 Months)
  • Change in Body Mass Index(Baseline; 3 Months)
  • Change in Self-Reported Quality of Life(Baseline; 3 Months)

Study Sites (4)

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