Effect of platelet activating factor receptor antagonist on acute ischemic and its anti-thrombotic and anti-inflammatory mechanism
- Conditions
- acute ischemic stroke
- Registration Number
- ITMCTR2100004815
- Lead Sponsor
- Zhaoqing First People's Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
1) Diagnosis of an acute ischemic stroke was confirmed using brain magnetic resonance imaging within the onset time=72 hours;
2) signs and symptoms of neurological deficit, and duration > 6 hours;
3) National Institutes of Health Stroke Scale (NIHSS) score of patient at admission >= 3;
4) Age:18 to 90 years-old.
1) Intracranial hemorrhagic identified by admission computed tomography (CT) scan or bleeding tendency;
2) Platelet count < 100 x 10^9/L, or > 450 x 10^9/L in the peripheral blood;
3) Coexisting severe systemic diseases, including severe heart diseases, hepatic and renal insufficiency, cancers, blood diseases or autoimmune diseases;
4) Major surgery in recent 4 weeks;
5) History of using other non-steroidal anti-inflammatory drugs, such as cilostazol, dipyridamole, warfarin, new oral anticoagulant drugs (NOACs) and low molecular weight heparin;
6) Administration of intravenous thrombolysis or/and intra-arterial thrombectomy treatment;
7) Ginkgo diterpene lactones contraindications.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method early neurological function deterioration;neurological function at 90 day;
- Secondary Outcome Measures
Name Time Method Intracranial hemorrhagic transformation;ischemic stroke recurrent;