Applicability of Platelet Rich Fibrin (PRF) in closure of non-healing Sternum wound

Phase 2

Recruiting

Conditions: Sternal Wound Repair.
Sternal manubrial dissociation, subsequent encounter for fracture with delayed healing
S22.23XG

Registration Number: IRCT20170221032714N4

Lead Sponsor: Tabriz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 10

Inclusion Criteria

The patient has been diagnosed with an acute STEMI or NSTEMI (confirmed by segment elevation (ST) changes on serial ECG, elevated troponin, coronary artery stenosis or occlusion identified by angiography, and a wall motion abnormality identified by angiography or echocardiography); The patient is scheduled to undergo coronary artery bypass surgery;The patient does not possess any contraindication for cardiovascular magnetic resonance (CMR); The patient is capable of giving informed consent; The patient is geographically accessible and willing to return for all follow-up investigations and clinical visits associated with study.

Exclusion Criteria

The Exclusion criteria of study: The patient is over the age of 65 years; The patient has previous myocardial infarction (MI) (other than the qualifying event) and/or has scar or non-viable myocardium identified by CMR in any other left ventricular (LV) territory; The patient is undergoing other cardiac surgery (i.e. concurrent cardiac valve, or aortic surgery); The patient requires emergency surgery (i.e. operative intervention (CABG or ventricular assist device) within 24-hrs of assessment); The patient has undergone previous cardiac surgery; The patient's post-surgical life expectancy is less than 45 days, in the investigator's opinion; The patient is of excessively poor baseline health, health-related quality of life, or physical functioning that would preclude a reasonable expected post-operative recovery; The patient has received radiotherapy to the chest wall, is receiving immunosuppressive therapy, or is in any way immunocompromised.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The bone formation in sternum. Timepoint: post operative- until release from hospitalization up to 1 month. Method of measurement: Cardiothoracic surgeon by assessment of photos which are taken from wound site.

Secondary Outcome Measures

Name	Time	Method
Scar formation or wound infection. Timepoint: post operative- until release from hospitalization up to 1 month. Method of measurement: by cardiothoracic surgeon and sample bacterial culture.