Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus

Phase 1

• Conditions: Atrophic Oral Lichen Planus; Erosive Oral Lichen Planus
• Interventions: Drug: Quercetin; Drug: placebo

• Registration Number: NCT01375101
• Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary

Lichen planus (LP) is a common chronic inflammatory mucocutaneous disease with an immunologic etiology ,which has number of different clinical forms. Alternative natural or herbal origine drugs with antioxidant and anti-inflammatory properties have been used individually or in combination with systemic corticosteroids in order to decrease adverse drug reactions.

This study was conducted to evaluate the effect of quercetin on treatment of erosive -atrophic lesions of oral lichen planus (OLP).

Detailed Description

Not available

Study Timeline

• Study Start: 2010-04
• Study First Submitted: 2011-06-14
• Study First Submitted QC: 2011-06-16
• Study First Posted: 2011-06-17
• Status Verified: 2011-07
• Last Update Submitted: 2011-07-25
• Last Update Posted: 2011-07-26
• Primary Completion: 2011-09
• Study Completion: 2011-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• confirmation of clinical diagnosis of Atrophic and erosive lichen planus by histological examination
• two weeks wash out periods after the last treatment
• having the experience of atrophic and erosive lesion greater than 1 cm having the experience of pain and burning greater than 3.5 in VAS Score

Exclusion Criteria

• confirmation of dysplasia and malignancy in histologic examination
• confirmation of lichenoid reaction in histologic examination
• pregnancy and breast feeding
• using fluorokinolon and cyclosporin which interact with quercetin

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
quercetin	Quercetin	quercetin is one of flavonoids , and having therapeutical anti-inflammatory and antioxidant action
placebo	placebo	placebo capsul is produced with lactose for using in placebo/ control group.

Primary Outcome Measures

Name	Time	Method
the effects of this Drug on OLP measured with VAS scale for pain and evaluation of intensity of lesions.	2 months	In the present work the Analogical Visual Scale is used TO evaluate pain,and we also record the intensity of lesions weekly and any side effect of this Drug

Trial Locations

Locations (1)

Mashhad university of Medical science, Research Center of oral and maxillofacial medicine; 🇮🇷 Mashhad, Khorasan Razavi, Iran, Islamic Republic of