The Effect of Quercetin in Sarcoidosis

Not Applicable

Completed

• Conditions: Sarcoidosis
• Interventions: Other: placebo; Dietary Supplement: quercetin

• Registration Number: NCT00402623
• Lead Sponsor: Maastricht University Medical Center

Brief Summary

The exact cause of the chronic lung disease sarcoidosis is still unknown. Consequently, a complete efficacious treatment is still not available. Earlier studies indicate an important key role for oxidative stress, i.e. an imbalance between the production of and the protection against ROS, in the etiology of sarcoidosis. Antioxidants, needed for protection against ROS, are indeed lower in sarcoidosis. Therefore, antioxidant therapy to strengthen the reduced antioxidant defense might be efficacious in sarcoidosis treatment. Since ROS are also capable of initiating and mediating inflammation, antioxidant therapy might also mitigate the elevated inflammation that occurs in sarcoidosis. The flavonoid quercetin possesses both anti-oxidative and anti-inflammatory capacities and might therefore serve as a good candidate for antioxidant therapy in sarcoidosis.

Therefore, the aim of the present study is to determine the effect of quercetin supplementation in sarcoidosis patients on markers of both oxidative stress and inflammation.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-01
• Primary Completion: 2006-01
• Study Completion: 2006-01
• Study First Submitted: 2006-11-20
• Study First Submitted QC: 2006-11-21
• Study First Posted: 2006-11-22
• Status Verified: 2008-02
• Last Update Submitted: 2017-02-22
• Last Update Posted: 2017-02-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• clinical diagnosis of sarcoidosis with emphasize on pulmonary sarcoidosis
• no smoking
• no treatment

Exclusion Criteria

• clinical diagnosis (and treatment) of other diseases
• symptoms of sarcoidosis in other organs besides the lung
• use of food supplements or vitamins

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	placebo	placebo
2	quercetin	quercetin (food supplement)

Primary Outcome Measures

Name	Time	Method
antioxidant status after 24 hours	24 hours
inflammatory status after 24 hours	24 hours

Secondary Outcome Measures

Name	Time	Method
plasma quercetin concentration after 24 hours	24 hours
plasma malondialdehyde (MDA) levels after 24 hours	24 hours

Trial Locations

Locations (1)

Maastricht University; 🇳🇱 Maastricht, Netherlands