First-line Surgical Versus Medical Treatment: A Retrospective Study From 2014 to 2024 in Brest
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 170
- 试验地点
- 1
- 主要终点
- Best-corrected visual acuity (BCVA) measured in logarithm of the minimum angle of resolution (logMAR) at 1 month
研究概览
简要总结
The goal of this observational cohort study is to evaluate the impact of early pars plana vitrectomy (PPV) on visual outcomes in adults diagnosed with acute endophthalmitis. It also aims to identify prognostic factors associated with visual recovery.
The main questions it aims to answer are:
Does early PPV (within 48 hours of diagnosis) improve visual acuity at 1 month compared with initial medical management? Which baseline clinical and microbiological factors are associated with worse visual outcomes?
Participants with acute endophthalmitis receiving standard care in routine clinical practice will be included. Patients undergoing early PPV will be compared with those receiving initial medical treatment alone or with delayed PPV to assess differences in visual outcomes.
Clinical data, including visual acuity, treatment characteristics, microbiological findings, and complications, will be collected retrospectively from medical records, with follow-up outcomes assessed at 1, 3, and 6 months.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •Clinically diagnosed acute endophthalmitis
- •Onset within 6 weeks following intraocular procedure (cataract surgery, intravitreal injection, anterior or posterior segment surgery)
- •Endophthalmitis associated with trauma, infectious keratitis, bleb-related infection, or endogenous infection
- •Availability of clinical data including visual acuity and treatment information
排除标准
- •Age < 18 years
- •Chronic endophthalmitis (> 6 weeks after procedure)
- •Non-infectious conditions (e.g., toxic anterior segment syndrome, postoperative inflammatory reaction)
- •Documented refusal or opposition to use of clinical data
- •Insufficient clinical data, particularly missing visual acuity or treatment informationcuity or treatment information
结局指标
主要结局
Best-corrected visual acuity (BCVA) measured in logarithm of the minimum angle of resolution (logMAR) at 1 month
时间窗: 1 month after diagnosis of acute endophthalmitis
Best-corrected visual acuity (BCVA), measured using the logarithm of the minimum angle of resolution (logMAR) scale, assessed at 1 month after diagnosis of acute endophthalmitis.
次要结局
未报告次要终点