The Effects of Administration of Vitamin E on Colistin Associated Nephrotoxicity

Phase 3

Recruiting

• Conditions: colistin associated nephrotoxicity.

• Registration Number: IRCT20130917014693N8
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 26 August 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

candidate to receive colistin to treat infection with positive blood culture for multi-drug resistance gram negative organism which is sensitive to colistin
pneumonia with positive tracheal culture for multi-drug resistance gram negative organism which is sensitive to colistin
urinary tract infection with positive urinary culture for multi-drug resistance gram negative organism which is sensitive to colistin
meningitis with positive Cerebrospinal fluid culture for multi-drug resistance gram negative organism which is sensitive to colistin
receiving colistin for at least one week

Exclusion Criteria

Chronic kidney disease
Acute kidney injury
Receiving amphotericin B
Receiving intravenous ascorbic acid
Active bleeding
Pregnancy
Patient's death

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum creatinine. Timepoint: baseline then daily to the end of colistin administration. Method of measurement: blood sample.;Glomerular filtration rate. Timepoint: baseline then daily to the end of colistin administration. Method of measurement: Cockcroft-Gault Formula.;Blood urea nitrogen. Timepoint: baseline then daily to the end of colistin administration. Method of measurement: blood sample.;Urinary output. Timepoint: baseline then daily to the end of colistin administration. Method of measurement: Measuring patient's urine volume.