Effectiveness evaluation of hypertonic dextrose therapy in knee osteoarthritis

Phase 3

Recruiting

Conditions: Knee Osteoarthrits.
Primary generalized (osteo)arthritis
M15.0

Registration Number: IRCT20190921044831N2

Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 80

Inclusion Criteria

All patients with mild to moderate knee osteoarthritis aged 45-75 years according to Kellgren-Lawrence criteria and rheumatologist approval
Absence of rheumatic diseases such as Rheumatoid Arthritis
Pain and tenderness of the knee joint resistant to medicine and conservative therapy for 3 months

Exclusion Criteria

Pregnancy
Medicine allergy to Oxycodone and Lidocaine
40kg/m2History of previous prolotherapy
Loosening of ligaments and knee joint
History of diabetes
History of hematologic disease, especially with palpitations
History of taking anticoagulants such as Plavix and warfarin
History of joint injection in the last 3 months
History of inflammatory joint disease and history of knee joint infection
People who are candidates for knee surgery with grade 4 based on Kellgren-lawrence
History of joint replacement and presence of joint prosthesis

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Score of WOMAC questionnaire. Timepoint: 4, 8, 12, 16, 20, 24 weeks after injection. Method of measurement: Score of WOMAC questionnaire.

Secondary Outcome Measures

Name	Time	Method
Clinical and functional status of the joint and persistence of the drug for 6 months after ending the treatment. Timepoint: 6 months after ending the treatment. Method of measurement: Questionnaire and clinical assessment.