NCT06696963已完成不适用
Impact of Time to Initiation of Postoperative Adjuvant Chemotherapy Following Neoadjuvant Chemotherapy on the Prognosis of Locally Advanced Gastric Cancer: a Multi-center Study
Fujian Medical University1 个研究点 分布在 1 个国家目标入组 524 人开始时间: 2024年3月15日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 524
- 试验地点
- 1
- 主要终点
- 3-year all-caused mortality, 3-year Gastric-Cancer Specific Motality
研究概览
简要总结
he present study retrospectively analyzed the clinicopathological data of 524 patients diagnosed with LAGC who underwent D2 radical gastrectomy after NACT between January 2010 and December 2021 at 2 centers. This study was conducted in accordance with the ethical principles outlined in the World Medical Association's Declaration of Helsinki. Informed consent was obtained from all patients and their legal guardians. All procedures were approved by the institutional review board.
详细描述
This is a retrospective, multicenter study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 84 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •(1) Locally advanced gastric cancer with preoperative clinical staging of cT2-4NxM0 before neoadjuvant chemotherapy. (2) No history of other malignant tumors. (3) No evidence of distant metastasis or invasion of adjacent organs. (4) Underwent gastrectomy after receiving neoadjuvant chemotherapy.
排除标准
- •(1) History of prior gastrectomy. (2) History of acute cardiovascular diseases (such as cerebral or coronary artery injuries) within the past three months. (3) Emergency surgery. (4) Did not undergo postoperative adjuvant chemotherapy. (5) Lack of specific information regarding chemotherapy regimens. (6) Loss to follow-up.
结局指标
主要结局
3-year all-caused mortality, 3-year Gastric-Cancer Specific Motality
时间窗: 3 years or 36 months.
Survival status at 3 years: survival, death, survival with tumor
次要结局
未报告次要终点
研究者
Chang-Ming Huang, Prof.
M.D. FACS
Fujian Medical University
研究点 (1)
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