Impact of target-volume noninvasive positive pressure ventilation on sleep: A randomized cross-over trial

Not Applicable

• Conditions: J96.1; Chronic respiratory failure; J44; Other chronic obstructive pulmonary disease

• Registration Number: DRKS00000450
• Lead Sponsor: niversitätsklinikum Freiburg, Abteilung Innere Medizin V - Pneumologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-10-05
• Study Completion: 2011-02-15
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

COPD patients with stable hypercapnic chronic respiratory failure (CRF) on NPPV (>3months) will be enrolled.

Exclusion Criteria

Patients who presented with an acute exacerbation (respiratory frequency >30 breaths/min, pH <7.30 or clinical signs of infection), those planned for weaning from invasive ventilation or those who had been intubated or tracheotomized during the previous 3 months will be excluded.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sleep efficiency (comparison between NPPV with and without target volume)

Secondary Outcome Measures

Name	Time	Method
sleep stages, nighttime events, alveolar ventilation at nighttime, subjective sleep quality and quality of life by questionnaires (comparison between NPPV with and without target volume)