Investigation of Vascular Pathology in Eye Diseases Using Using Optical Coherence Tomography Angiography (OCT-A)
- Conditions
- Retinal Disease
- Interventions
- Device: optical coherence tomography angiography
- Registration Number
- NCT02811536
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Brief Summary
Comparison of OCTA to conventional imaging modalities for the diagnosis of eye diseases
- Detailed Description
Optical coherence tomography angiography (OCTA) is a new non-invasive imaging technique that employs motion contrast imaging to high-resolution volumetric blood flow information. OCTA compares the decorrelation signal between sequential OCT b-scans taken at precisely the same cross-section in order to construct a map of blood flow. At present, level 1 evidence of the technology's clinical applications doesn't exist. The investigators plan to compare OCTA as an imaging modality to conventional imaging modalities used in clinical routine.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 440
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Diabetic retinopathy optical coherence tomography angiography Patients with various degrees of diabetic retinopathy Retinal detachment optical coherence tomography angiography Patients with a history of retinal detachment Arterial hypertension optical coherence tomography angiography Patients with a history of arterial hypertension Retinal vein occlusion optical coherence tomography angiography Patients with a history of retinal vein occlusion Carotid artery occlusion optical coherence tomography angiography Patients with a history of carotid artery occlusion Age related macular degeneration optical coherence tomography angiography Patients with a history of Age related macular degeneration Macroaneurysms optical coherence tomography angiography Patients with a history of retinal macroaneurysms Central serous chorioretinopathy optical coherence tomography angiography Patients with a history of central serous chorioretinopathy
- Primary Outcome Measures
Name Time Method Evaluation of the sensitivity and specificity of OCTA 2 years The primary objective of this observational study is to evaluate the sensitivity and specificity to diagnose vascular abnormalities with OCTA compared to conventional imaging methods. The main parameter that will be assessed is area of nonperfusion of the retina. The incidence (binary) of nonperfusion areas will be assessed in OCTA and compared to conventional imaging methods such as fluorescein angiography.
- Secondary Outcome Measures
Name Time Method Evaluation of the intra-and inter-reader reproducibility of the diagnosis of vascular abnormalities using OCTA 2 years The primary objective of this observational study is to evaluate the sensitivity and specificity to diagnose vascular abnormalities with OCTA compared to conventional imaging methods. The main parameter that will be assessed is area of nonperfusion of the retina. The incidence (binary) of nonperfusion areas will be assessed in OCTA and compared to conventional imaging methods such as fluorescein angiography.
OCTA and Fundus color photographs 2 years Evaluation whether pathological changes seen in OCT or color fundus photography correlate with changes seen in OCTA
Subgroup analysis 2 years Subgroup analysis will be performed with patients suffering from diabetic retinopathy, artery occlusion, carotid stenosis, retinal detachment, vein occlusion, age related macular degeneration, retinal changes from arterial hypertension, retinal macroaneurysms and uveitis.
Trial Locations
- Locations (1)
Inselspital Bern, Department of Ophthalmology
🇨ðŸ‡Bern, Switzerland