OCTA Study: Retinal Vascular Changes in Patients With SARS-CoV-2 Infection

Completed

• Conditions: Covid19
• Interventions: Diagnostic Test: Optical coherence tomography angiography

• Registration Number: NCT04601012
• Lead Sponsor: Federico II University

Brief Summary

This study evaluates the retinal vascular features using optical coherence tomography angiography in patients that have been affected by COVID-19.

Detailed Description

To investigate the potential role of optical coherence tomography angiography in identifying the changes in retinal vessel density in patients that have been affected by COVID-19.

The optical coherence tomography angiography represents a noninvasive diagnostic technique that allows a detailed analysis of retinal vascular features.

Study Timeline

• Study Start: 2020-09-20
• Status Verified: 2020-10
• Primary Completion: 2020-10-20
• Study Completion: 2020-10-22
• Study First Submitted: 2020-10-22
• Study First Submitted QC: 2020-10-22
• Study First Posted: 2020-10-23
• Last Update Submitted: 2021-01-14
• Last Update Posted: 2021-01-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• age older than 18 years
• diagnosis of previous COVID-19
• absence of previous ocular surgery, congenital eye disease, high myopia (>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
• absence of significant lens opacities, low-quality OCT and OCT-A images.

Exclusion Criteria

• age younger than 18 years
• absence of previous diagnosis of COVID-19
• presence of previous ocular surgery, congenital eye disease, high myopia (>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
• presence of significant lens opacities, low-quality OCT and OCT-A images.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with COVID19	Optical coherence tomography angiography	The patients with previous diagnosis of COVID19
Control subjects	Optical coherence tomography angiography	Healthy subjects without actual and previous ocular diseases

Primary Outcome Measures

Name	Time	Method
The measurements of retinal features in patients with previous diagnosis of COVID19, using optical coherence tomography angiography.	one month	The parameter analyzed by optical coherence tomography angiography was: retinal vessel density

Trial Locations

Locations (1)

University of Naples "Federico II"; 🇮🇹 Naples, Italy