Investigation of Vascular Pathology in Eye Diseases Using Using Optical Coherence Tomography Angiography (OCT-A)
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 440
- Locations
- 1
- Primary Endpoint
- Evaluation of the sensitivity and specificity of OCTA
Study Overview
Brief Summary
Comparison of OCTA to conventional imaging modalities for the diagnosis of eye diseases
Detailed Description
Optical coherence tomography angiography (OCTA) is a new non-invasive imaging technique that employs motion contrast imaging to high-resolution volumetric blood flow information. OCTA compares the decorrelation signal between sequential OCT b-scans taken at precisely the same cross-section in order to construct a map of blood flow. At present, level 1 evidence of the technology's clinical applications doesn't exist. The investigators plan to compare OCTA as an imaging modality to conventional imaging modalities used in clinical routine.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Evaluation of the sensitivity and specificity of OCTA
Time Frame: 2 years
The primary objective of this observational study is to evaluate the sensitivity and specificity to diagnose vascular abnormalities with OCTA compared to conventional imaging methods. The main parameter that will be assessed is area of nonperfusion of the retina. The incidence (binary) of nonperfusion areas will be assessed in OCTA and compared to conventional imaging methods such as fluorescein angiography.
Secondary Outcomes
- Evaluation of the intra-and inter-reader reproducibility of the diagnosis of vascular abnormalities using OCTA(2 years)
- OCTA and Fundus color photographs(2 years)
- Subgroup analysis(2 years)