Imaging of Retinochoroidal Vasculature in Patients Being Assessed for Cardiovascular Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiovascular Diseases
- Sponsor
- Northwestern University
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Correlation with and prediction of the presence/degree of carotid occlusive disease as determined by carotid duplex ultrasonography
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
This study aims to determine whether changes in retinal vasculature seen on SS-OCTA can be correlated to degree of cardiovascular disease as measured by carotid duplex ultrasonography.
Detailed Description
The study's primary objective is to determine whether measures taken from SS-OCTA, color fundus photography, and retinal exams can correlate with and predict the presence/degree of carotid occlusive disease as determined by carotid duplex ultrasonography by examining the following parameters: retinal vessel caliber, retinal vessel density, retinal vessel perfusion, retinal vessel tortuosity, presence of Hollenhorst or other plaques, and/or areas of ischemia.
Investigators
Rukhsana Mirza
Principal Investigator, M.D., MS
Northwestern University
Eligibility Criteria
Inclusion Criteria
- •Subjects between 18 and 80 years of age.
- •No known prior history of retinal disease.
- •Able to participate in a clinical eye examination setting.
- •Able to consent.
- •Subjects receiving standard of care carotid duplex ultrasounds.
Exclusion Criteria
- •Known ophthalmologic disease (e.g. glaucoma, macular degeneration, ocular injury) other than corrected refractive error.
- •Lack of capacity to provide informed consent.
- •Subjects younger than 18 years of age or older than 80 years of age.
- •History of stroke or acute loss of vision.
- •Unable to participate in a clinical eye examination setting.
Outcomes
Primary Outcomes
Correlation with and prediction of the presence/degree of carotid occlusive disease as determined by carotid duplex ultrasonography
Time Frame: 2 hours
Determining whether measures taken from SS-OCTA, color fundus photography, and retinal exams can correlate with and predict the presence/degree of carotid occlusive disease as determined by carotid duplex ultrasonography by examining the following parameters: retinal vessel caliber, retinal vessel density, retinal vessel perfusion, retinal vessel tortuosity, presence of Hellenhorst or other plaques, and/or areas of ischemia.