Diagnostic Study of Quantitative Imaging and Spectroscopy in Patients With Multiple Sclerosis

National Center for Research Resources (NCRR)1 site in 1 country100 target enrollmentApril 1999

ConditionsMultiple Sclerosis

Drugsstandard gadolinium contrast

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Multiple Sclerosis
Sponsor: National Center for Research Resources (NCRR)
Enrollment: 100
Locations: 1
Last Updated: 17 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

OBJECTIVES: I. Determine by quantitative magnetic resonance imaging measurements the change in the total volume of brain parenchyma as well as its gray and white matter, T2 and enhanced T1 lesion volume, and the magnetization transfer ratio histogram parameters, and correlate these measurements with clinical measures of disability in patients with multiple sclerosis.

II. Measure the quantity of whole brain N-acetylaspartate in patients with multiple sclerosis and compare these values to those from age matched controls.

III. Determine the correlation between specific neuropsychological tests which assess global cognitive functioning and the quantitative measurements taken in these patients in this study.

Detailed Description

PROTOCOL OUTLINE: Patients undergo magnetic resonance imaging and spectroscopy with standard gadolinium contrast followed by neuropsychological testing every 6 months for 5 years. An equal number of age and sex matched healthy patients act as a control group and undergo magnetic resonance imaging and spectroscopy without standard gadolinium contrast every 6 months for 5 years.

Registry

clinicaltrials.gov

Start Date

April 1999

End Date

TBD

Last Updated

17 years ago

Study Type

Observational

Sex

All