Quantitative MR Imaging and Proton Spectroscopy in MS
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 69
- 试验地点
- 1
- 主要终点
- Assess the MS lesions using Magnetization transfer ratio histogram parameters and compare it to total brain parenchymal volume
研究概览
简要总结
The primary purpose of this study is to detect changes in the brain that may be associated with multiple sclerosis. Results will be compared to age matched controls. Investigators will assess lesions by measuring T2 and T1 enhanced lesion volumes and magnetization transfer ratio histogram parameters (MTRHP) in patients with relapsing-remitting and secondary-progressive disease. This data will be correlated to total brain parenchymal volume as well as identifying the effect of MS lesions on the gray and white matter, volumetric disability, including Kurtzke Expanded Disability Status Scale (EDSS) and a specific battery of neuropsychological tests. Quantitative analysis of whole brain N-acetylaspartate (WBNAA), a reproducible measure of viable neuron number, using 1H MRS and compare the results to age-matched controls over duration of 5 years.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 7 Years 至 110 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with known MS diagnosis
- •Age 7-110 years
- •Males or females
排除标准
- •Medically unstable
- •Artificial implants in the body
- •Normal Controls
研究组 & 干预措施
MS Patients
All subjects enrolled in this study will undergo MRI studies. A computerized neuropsychological battery of tests will be administered.
干预措施: Magnetic Resonance Imaging (Device)
Healthy Patients
Patients enrolled in this study will undergo MRI studies. A computerized neuropsychological battery of tests will be administered.
干预措施: Magnetic Resonance Imaging (Device)
结局指标
主要结局
Assess the MS lesions using Magnetization transfer ratio histogram parameters and compare it to total brain parenchymal volume
时间窗: 5 years
1) Lesions will be assessed by measuring T2 and T1 enhanced lesion volumes and magnetization transfer ratio histogram parameters (MTRHP) in patients with relapsing-remitting and secondary-progressive disease. This data will be correlated to total brain parenchymal volume as well as identifying the effect of MS lesions on the gray and white matter, volumetric disability, including Kurtzke Expanded Disability Status Scale (EDSS) and a specific battery of neuropsychological tests
次要结局
- Quantitative analysis of whole brain N-acetylaspartate (WBNAA)(5 years)