Quantitative MR Imaging and Proton Spectroscopy in MS
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- NYU Langone Health
- Enrollment
- 69
- Locations
- 1
- Primary Endpoint
- Assess the MS lesions using Magnetization transfer ratio histogram parameters and compare it to total brain parenchymal volume
- Status
- Terminated
- Last Updated
- 8 years ago
Overview
Brief Summary
The primary purpose of this study is to detect changes in the brain that may be associated with multiple sclerosis. Results will be compared to age matched controls. Investigators will assess lesions by measuring T2 and T1 enhanced lesion volumes and magnetization transfer ratio histogram parameters (MTRHP) in patients with relapsing-remitting and secondary-progressive disease. This data will be correlated to total brain parenchymal volume as well as identifying the effect of MS lesions on the gray and white matter, volumetric disability, including Kurtzke Expanded Disability Status Scale (EDSS) and a specific battery of neuropsychological tests. Quantitative analysis of whole brain N-acetylaspartate (WBNAA), a reproducible measure of viable neuron number, using 1H MRS and compare the results to age-matched controls over duration of 5 years.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients with known MS diagnosis
- •Age 7-110 years
- •Males or females
Exclusion Criteria
- •Medically unstable
- •Artificial implants in the body
- •Normal Controls
Outcomes
Primary Outcomes
Assess the MS lesions using Magnetization transfer ratio histogram parameters and compare it to total brain parenchymal volume
Time Frame: 5 years
1) Lesions will be assessed by measuring T2 and T1 enhanced lesion volumes and magnetization transfer ratio histogram parameters (MTRHP) in patients with relapsing-remitting and secondary-progressive disease. This data will be correlated to total brain parenchymal volume as well as identifying the effect of MS lesions on the gray and white matter, volumetric disability, including Kurtzke Expanded Disability Status Scale (EDSS) and a specific battery of neuropsychological tests
Secondary Outcomes
- Quantitative analysis of whole brain N-acetylaspartate (WBNAA)(5 years)