Effectiveness and Reliability of Selected Site Pacing for Avoidance of Phrenic Nerve Stimulation in CRT Patients With Quadripolar LV Leads
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Heart Failure
- Sponsor
- Abbott Medical Devices
- Enrollment
- 337
- Locations
- 16
- Primary Endpoint
- Percentage of patients with at least one acceptable lead vector
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Cardiac resynchronization (CRT) therapy is well established for treatment of patients with severe heartfailure, reduced left ventricular (LV) function and ventricular dyssynchrony. Roughly 1/3 of CRT patients do not improve after CRT implant. One possible reason is interruption of biventricular pacing. This might be caused by several conditions, including elevated left ventricular (LV) pacing thresholds or presence of phrenic nerve stimulation (PNS). CRT devices with quadripolar LV leads offer 10 LV pacing vectors to choose from. It's the aim of this prospective observational study to investigate efficacy and reliability of cardiac resynchronization therapy (CRT) with quadripolar left ventricular leads.
Hypothesis: In more than 90% of patients, who received a CRT system with quadripolar LV lead, at least one acceptable LV lead vector is available.
Detailed Description
Definition of an acceptable lead vector: Any LV pacing vector that complies in both tested body positions (left lateral position and sitting) with both criteria: 1. Phrenic nerve stimulation threshold is at least twice as high as LV pacing threshold 2. LV pacing threshold is less or equals 2.5Volts (V) @0.5 milliseconds (ms)
Investigators
Eligibility Criteria
Inclusion Criteria
- •Indication for implantation of a CRT-D
- •Age \>= 18 years
- •Written informed consent
Exclusion Criteria
- •Already implanted LV or coronary sinus lead
- •Previous unsuccessful LV lead implant attempt
- •Patient is eligible for heart transplantation
- •Comorbidities that results in life expectancy of less than 12 months
- •Known pregnancy
- •Inability to provide written patient informed consent
- •Participation to another study with active treatment arm (i.e. randomized studies etc...)
- •Patient is not willing or is not able to visit the study center for the study assessments within the first 3 months after implant
- •Patient is not able to understand or answer the quality of life questionaire
Outcomes
Primary Outcomes
Percentage of patients with at least one acceptable lead vector
Time Frame: Pre hospital discharge (PHD) to 3 months
Definition of acceptable lead vector: Any LV vector that complies in both tested body positions with both criteria: 1. Phrenic nerve stimulation threshold is at least twice as high as LV pacing threshold 2. LV pacing threshold is less or equals 2.5V@0.5ms
Secondary Outcomes
- Quality of Life(Baseline to 3 months)
- Phrenic nerve stimulation (PNS)(PHD to 3 months)
- LV pacing thresholds(PHD to 3 months)
- Number of acceptable LV lead vectors per patient(PHD to 3 months)
- Finally programmed LV lead vector(PHD to 3 months)