Brain-behaviour relationship of physical inactivity, frailty and depression in the elderly

Recruiting

• Conditions: R54; F32; Senility; Depressive episode

• Registration Number: DRKS00027381
• Lead Sponsor: Sektion Neuropsychiatrie Klinik für Allgemeine PsychiatrieZentrum für Psychosoziale MedizinUniversitätsklinikum Heidelberg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-12-27
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Subjects with frailty
- Category = 5/9 of the Clinical Frailty Scale fulfilled (Rockwood et al. 2005)
- Criteria for a depressive disorder according to DSM-5 criteria (APA 2013) neither currently nor in the past fulfilled
- Age = 65 years
- male or female
- right-handed
Subjects with depression
- Depressive disorder according to DSM-5 criteria (APA 2013), at least moderate depressive symptomatology at study inclusion, i.e., HAMD score = 17 points (Zimmerman et al. 2013)
- Age = 65 years
- male or female
- Right-handed
Subjects with frailty and depression
- Category = 5/9 of the Clinical Frailty Scale met (Rockwood et al. 2005).
- Depressive disorder according to DSM-5 criteria (APA 2013), at least moderate depressive symptomatology at study inclusion, i.e., HAMD score = 17 points (Zimmerman et al. 2013)
- Age = 65 years
- male or female
- right-handed
Control subjects without frailty or depression.
- No frailty present according to Clinical Frailty Scale, i.e., category = 4/9 (Rockwood et al. 2005).
- Criteria for a depressive disorder according to DSM-5 criteria (APA 2013) neither currently nor in the past met, HAMD score < 7 points (Zimmerman et al. 2013)
- Age = 65 years
- male or female
- right-handed

Exclusion Criteria

- Incapacity to consent
- More than mild cognitive dysfunction (MMST score = 23 points) (Folstein et al. 1975).
- Criteria for a psychiatric disorder other than one defined as depression according to DSM-5 (APA 2013) currently or in the past met
- Neurodegenerative disease (clinical assessment), cerebral space-occupying lesion, large cerebral infarction (territorial infarction), severe cerebral microangiopathy
- history of traumatic brain injury
- Acute physical illness requiring intervention (e.g., decompensated cardiac insufficiency, febrile infection, etc.) or acute suicidal tendencies.
- medical condition that precludes the feasibility of the examinations (e.g. fracture, aphasia, etc.)
- MRI contraindications (MR-incompatible metallic foreign bodies, MR-incompatible pacemakers, claustrophobia)
- lack of SARS-CoV-2 immunization

Study & Design

• Study Type: observational
• Study Design: Not specified