DRKS00027381招募中不适用
Brain-behaviour relationship of physical inactivity, frailty and depression in the elderly
Sektion Neuropsychiatrie Klinik für Allgemeine PsychiatrieZentrum für Psychosoziale MedizinUniversitätsklinikum Heidelberg0 个研究点目标入组 120 人开始时间: 2021年12月27日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 120
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 65 Years 至 one（—）
- 性别
- All
入选标准
- •Subjects with frailty
- •- Category = 5/9 of the Clinical Frailty Scale fulfilled (Rockwood et al. 2005)
- •- Criteria for a depressive disorder according to DSM-5 criteria (APA 2013) neither currently nor in the past fulfilled
- •- Age = 65 years
- •- male or female
- •- right-handed
- •Subjects with depression
- •- Depressive disorder according to DSM-5 criteria (APA 2013), at least moderate depressive symptomatology at study inclusion, i.e., HAMD score = 17 points (Zimmerman et al. 2013)
- •- Age = 65 years
- •- male or female
- •- Right-handed
- •Subjects with frailty and depression
- •- Category = 5/9 of the Clinical Frailty Scale met (Rockwood et al. 2005).
- •- Depressive disorder according to DSM-5 criteria (APA 2013), at least moderate depressive symptomatology at study inclusion, i.e., HAMD score = 17 points (Zimmerman et al. 2013)
- •- Age = 65 years
- •- male or female
- •- right-handed
- •Control subjects without frailty or depression.
- •- No frailty present according to Clinical Frailty Scale, i.e., category = 4/9 (Rockwood et al. 2005).
- •- Criteria for a depressive disorder according to DSM-5 criteria (APA 2013) neither currently nor in the past met, HAMD score < 7 points (Zimmerman et al. 2013)
- •- Age = 65 years
- •- male or female
- •- right-handed
排除标准
- •- Incapacity to consent
- •- More than mild cognitive dysfunction (MMST score = 23 points) (Folstein et al. 1975).
- •- Criteria for a psychiatric disorder other than one defined as depression according to DSM-5 (APA 2013) currently or in the past met
- •- Neurodegenerative disease (clinical assessment), cerebral space-occupying lesion, large cerebral infarction (territorial infarction), severe cerebral microangiopathy
- •- history of traumatic brain injury
- •- Acute physical illness requiring intervention (e.g., decompensated cardiac insufficiency, febrile infection, etc.) or acute suicidal tendencies.
- •- medical condition that precludes the feasibility of the examinations (e.g. fracture, aphasia, etc.)
- •- MRI contraindications (MR-incompatible metallic foreign bodies, MR-incompatible pacemakers, claustrophobia)
- •- lack of SARS-CoV-2 immunization
研究者
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