Acute Immunological Effects of Exercise in Cancer Patients

Phase 2

Active, not recruiting

• Conditions: Cancer
• Interventions: Behavioral: High intensity interval exercise training

• Registration Number: NCT05656651
• Lead Sponsor: Universität Duisburg-Essen

Brief Summary

The aim of the study is to evaluate and compare immune response to a single exercise intervention in cancer patients and healthy age-maged individuals.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-11-13
• Study First Submitted QC: 2022-12-12
• Study Start: 2022-12-19
• Study First Posted: 2022-12-19
• Primary Completion: 2024-07-31
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-03
• Last Update Posted: 2024-12-06
• Study Completion: 2025-07

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Adolescents and young adults >14 years of age
• undergoing acute cancer treatment (chemotherapy)
• signed informed consent

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Exclusion Criteria

• Inability to follow and implement test instructions
• medical contraindication to HIIT on cycle ergometer
• chemotherapeutic treatment 48 h prior
• Hb <8g/dl; platelets < 20,000/ul.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cancer patients	High intensity interval exercise training	Single exercise intervention following a HIIT protocol, duration \~20 mins
Healthy adults	High intensity interval exercise training	Single exercise intervention following a HIIT protocol, duration \~20 mins

Primary Outcome Measures

Name	Time	Method
Number of Natural Killer Cells	Change from pre Intervention to immediately after intervention and 1 hour post intervention	NK cells, subgroups and innate lymphoid cells

Secondary Outcome Measures

Name	Time	Method
Fatigue	Once after intervention	Fatigue (EORTC QLQ FA12 Fatigue questionnaire range 0 - 100, higher score = worse outcome)
Subjective Quality of Life	Once after intervention	Quality of Life (EORTC QLQ-C30, questionnaire score from 0 - 100, higher score = better quality of life)
Nutritional status	Once after intervention	Mini Nutritional Assessment (MNA range 0 - 14 points), lower score = worse

Trial Locations

Locations (1)

University Hospital Essen; 🇩🇪 Essen, NRW, Germany