Molecular Analysis for Gastro-Esophageal Cancer: Multicenter Discrete Choice Experiment

Not Applicable

Recruiting

• Conditions: Esophageal Cancer; Gastric Cancer
• Interventions: Other: Survey

• Registration Number: NCT06346080
• Lead Sponsor: KU Leuven

Brief Summary

The goal of this survey is to investigate the participants' preference for a specific screening/diagnostic tool to detect and assess gastro-esophageal cancer.

The main question it aims to answer are:

* Which diagnostic modality is preferred by patients and the general population?

* Which features of the diagnostic test are most detrimental in the decision-making for one or the other modality?

* Are geographical differences present in regard to the preference for a diagnostic modality?

Participants will be asked to complete a survey of 20-25min, including a brief intake regarding their socio-economic status. This approach will allow us to correct for confounding factors.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-03-23
• Study First Submitted QC: 2024-03-28
• Study First Posted: 2024-04-03
• Status Verified: 2024-08
• Study Start: 2024-08-01
• Last Update Submitted: 2024-08-20
• Last Update Posted: 2024-08-22
• Primary Completion: 2026-08-01
• Study Completion: 2026-08-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 2200

Inclusion Criteria

1. Individuals >18yo to 75yo (upper age limit of Barrett's surveillance)
2. Access to computer or smartphone
3. Clear understanding of available languages of the experiment (English, French, Dutch, Spanish, German, Chinese, Japanese)

Exclusion Criteria

1. Individuals less than 18yo and more than 75yo
2. Incarcerated individuals

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Survey participants	Survey	Participants who will complete a survey investigating their preference for diagnosis and assessment of gastro-esophageal cancer

Primary Outcome Measures

Name	Time	Method
The percentage differences in preference of participants between geographical regions	2 years	Differences in preferences will be compared between different geographical regions using chi-squared or McNemar's test
The rate of contribution of diagnostic features to the preference of participants	2 years	A part-worth analysis, expressed as percentage, from a discrete choice experiment (questionnaire) will assess the features that are most important to the participants

Secondary Outcome Measures

Name	Time	Method
Assess the rate of trade-off demonstrated as odds ratio between cancer-related mortality reduction and costs	2 years	Based on an anticipated cancer detection and cost, we will assess the willingness-to-pay using a multivariable logistic regression, providing odds ratios.
Assess the rate patient-level demographics influence the importance of a test feature, expressed as an odds ratio	2 years	Assess the influence of demographic characteristics on the decision-making process using a multivariable logistic regression model, providing odds ratios.

Trial Locations

Locations (1)

University Hospitals Leuven; 🇧🇪 Leuven, Belgium