Effect of high intensity resistance and impact training on fracture risk in postmenopausal women with low bone mass who may or may not be on antiresorptive bone medication: the MEDEX-OP trial

Griffith University0 个研究点目标入组 116 人开始时间: 2017年10月27日最近更新: 2021年4月12日

适应症

试验速览

暂无简介。

•Postmenopausal women (>=5 years)
•- Low bone mass (BMD > 1 SD below age-matched mean)
•- Community ambulant without walking aid
•- Good general health
•- Taking antiresorptive agents (bisphosphonate or denosumab) for at least 12 months OR not taking bone medication and not intending to change this choice for the study period of 8 months

•- Lower limb joint injury or surgery
•- Recent fracture or acute moderate to severe back pain (previous 6 months)
•- Malignancy or currently receiving chemotherapy or radiation therapy
•- Cognitive impairment
•- Contraindications for participating in heavy physical activity;
•- Conditions known to influence bone health (e.g. thyrotoxicosis or hyperparathyroidism, Paget’s disease, renal disease, diabetes, immobility)
•- Taking medications known to negatively influence bone health (e.g. prolonged use of corticosteroids, thyroxine, thiazides or antiretroviral agents).
•- Medical conditions that would prevent completion of either of the two exercise programs (e.g. uncontrolled cardiovascular disease, nerve disorder, spinal cord injuries)
•- Lifestyle choices that prevent adherence to either of the two exercise programs for the intervention duration (e.g. longer than 3 week planned holiday in the next 8 months, etc.)

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