Sequential Intrathecal Injection of Fentanyl and Hyperbaric Bupivacaine
- Conditions
- Elective Caesarean Section
- Interventions
- Registration Number
- NCT03415087
- Lead Sponsor
- Ain Shams University
- Brief Summary
56 Parturients, aged 18-40 year, undergoing elective CS were randomly assigned to receive sequential intrathecal injection of fentanyl and hyperbaric bupivacaine at the same rate (normal sequential) NS or a rapid intrathecal injection of fentanyl followed by slow injection of hyperbaric bupivacaine (rapid sequential) RS. Time of first rescue analgesia, Dose of rescue analgesics, degree of postoperative pain, incidence of hypotension, hypotension duration, ephedrine dose, spinal anaesthesia related complications and failed block were recorded.
- Detailed Description
56 ASA physical status I, II Parturients, aged 18-40 year, undergoing elective CS were randomly assigned to receive sequential intrathecal injection of fentanyl and hyperbaric bupivacaine at the same rate through a 5ml syringe each (NS (normal sequential), n 28) or a rapid intrathecal injection of fentanyl through an insuline syringe followed by slow injection of hyperbaric bupivacaine through a 5ml syringe RS (rapid sequential), n 28). Onset of sensory block (T6 level), highest level of sensory block, time of first rescue analgesia, Dose of rescue analgesics, degree of postoperative pain by VAS 6H postoperative, Onset of motor block (Bromage scale0\>3), duration of motor block (return to Bromage 0), incidence of hypotension, hypotension duration, ephedrine dose, spinal anaesthesia related complications as nausea, vomiting, pruritis, shivering and failed block were recorded.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 56
- ASA I, II
- Parturients aged from 18-40 years old
- scheduled for elective CS
- parturients with complicated pregnancy as (preeclampsia, pregnancy induced HTN, gestational Diabetes, abnormal placenta (placenta previa), multiple gestation),
- BMI greater than 35 or less than 22,
- major systemic disease (cardiac, renal, liver),
- need for emergency CS,
- having allergy to drugs used in the study,
- having contraindication for spinal anaesthesia or
- refused regional anaesthesia
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description sequential intrathecal injection of fentanyl and bupivacaine hyperbaric bupivacaine intrathecal injection drug: fentanyl 25 μg (0.5 ml), IV,once drug: hyperbaric bupivacaine 0.5%10 mg IV,once both syringes were injected slowly sequentially sequential intrathecal injection of fentanyl and bupivacaine sequential intrathecal injection intrathecal injection drug: fentanyl 25 μg (0.5 ml), IV,once drug: hyperbaric bupivacaine 0.5%10 mg IV,once both syringes were injected slowly sequentially rapid sequential intrathecal injection of fentanyl and bupiva sequential intrathecal injection intrathecal injection drug: fentanyl 25 μg (0.5 ml), IV, injected rapidly and mixed by CSF, once drug: hyperbaric bupivacaine 0.5%10 mg IV injected slowly once. rapid sequential intrathecal injection of fentanyl and bupiva hyperbaric bupivacaine intrathecal injection drug: fentanyl 25 μg (0.5 ml), IV, injected rapidly and mixed by CSF, once drug: hyperbaric bupivacaine 0.5%10 mg IV injected slowly once. sequential intrathecal injection of fentanyl and bupivacaine fentanyl intrathecal injection drug: fentanyl 25 μg (0.5 ml), IV,once drug: hyperbaric bupivacaine 0.5%10 mg IV,once both syringes were injected slowly sequentially rapid sequential intrathecal injection of fentanyl and bupiva fentanyl intrathecal injection drug: fentanyl 25 μg (0.5 ml), IV, injected rapidly and mixed by CSF, once drug: hyperbaric bupivacaine 0.5%10 mg IV injected slowly once.
- Primary Outcome Measures
Name Time Method Duration of postoperative analgesia 2-5 hours technique provides prolonged post operative analgesia
- Secondary Outcome Measures
Name Time Method incidence of hypotension 30 minutes note if hypotension occurs