Cerebral Vascular Reserve in Small Vessel Disease and Alzheimers Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Alzheimer Disease
- Sponsor
- Bispebjerg Hospital
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Vascular reserve perfusion
- Last Updated
- 3 years ago
Overview
Brief Summary
Alzheimers disease and cerebral small vessel disease have a considerably overlap in patients and have common risk factors. The diseases are difficult to separate in individual patients and we hypothesize that a reduced cerebral vascular reserve may be a measurement of small vessel disease independent of Alzheimers disease.
Patients with presumed Alzheimers disease (n=20), cerebral small vessel disease (n=20) and healthy age-matched subjects (n=15) are examined with quantitative [15O]H2O positron emission tomography (PET) for measurements of brain perfusion before and after diamox infusion that dilates cerebral vessels. Additional [15O]H2O PET scans of the heart allows for a non-invasive input function so the cerebral vascular reserve can be measured quantitatively.
Detailed Description
Alzheimers disease and cerebral small vessel disease are increasingly common in the elderly population and constitute around 90% of new dementia cases in Denmark. The diseases have a considerably overlap in patients and have common risk factors. The cause of dementia can be difficult to separate in individual patients but a reduced cerebral vascular reserve may be a measurement of small vessel disease independent of Alzheimers disease. We hypothesized that patient with small vessel disease have reduced increase in brain perfusion after medical brain vessel dilatation. While Alzheimer patients may have reduced perfusion in rest but normal increase after medical brain vessel dilatation as compared to healthy subjects. Patients with presumed Alzheimers disease (n=20), cerebral small vessel disease (n=20) and healthy age-matched subjects (n=15) are examined with quantitative \[15O\]H2O PET for measurements of brain perfusion before and after diamox infusion that dilates cerebral vessels. Additional \[15O\]H2O PET scans of the heart allows for a non-invasive input function so the cerebral vascular reserve can be measured quantitatively.
Investigators
Lisbeth Marner
MD, Associate professor
Bispebjerg Hospital
Eligibility Criteria
Inclusion Criteria
- •presumed Alzheimer's Disease (group 1)
- •diagnosed with small vessel disease of the brain by MRI and presumed cognitive dysfunction (group 2)
Exclusion Criteria
- •major claustrophobia
- •major psychiatric diseases
- •other major somatic diseases
- •allergy to diamox
Outcomes
Primary Outcomes
Vascular reserve perfusion
Time Frame: 20 min after diamox infusion
Brain perfusion after diamox infusion (mL / min / 100 g tissue)
Vascular reserve change
Time Frame: 20 min after diamox infusion
Change in Brain perfusion after diamox infusion (mL / min / 100 g tissue and %) compared to before diamox infusion