Acute effects of coffee and major coffee components on glucagon-like peptide 1 response and glucose tolerance in humans - Coffee consumption and glucose tolerance in humans

Vrije Universiteit0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年5月13日

适应症

试验速览

暂无简介。

•- Apparently healthy males as assessed by the questionnaires during the pre-study visit, and the results of the pre-study clinical laboratory tests and urinalysis
•- Age at screening: 18 years and above
•- Body mass index (BMI) between 25.0 and 35.0 kg/m2
•- Regular coffee consumer (1 cup per day or more)
•- Willing to restrict coffee consumption during the study to max. 1 cup per day
•- Voluntary participation
•- Willing not to be blood or plasmaferese donor from 4 weeks before the start of the study until the end of study

•- Subjects with diabetes will be excluded (fasting blood glucose >= 7.0 mmol/l or physician-diagnosis of diabetes)
•- Blood sampling is considered too difficult (assessed during pre-study screening)
•- Any chronic or acute disease (e.g. diabetes, renal disease, inflammation, cardiovascular disease). Therefore the medical questionnaire will be evaluated by a doctor from the research team.
•- Hypertension criteria for moderate hypertension WHO 2003: systolic > 140 mmHg or diastolic > 90 mmHg
•- Medical history or surgical events known to interfere with the study
•- Alcohol consumption > 28 consumptions per week
•- Self reported weight loss or gain > 2 kg in the month prior to screening
•- Any special diet (prescribed, slimming, macrobiotic or vegan). Sole exclusion of meat and fish from an otherwise *normal* western diet is allowed
•- Participation in any other trial up to 3 months before and during this study
•- Use of medication known to interfere with the study outcome e.g.: Medication interfering with digestion or glucose metabolism, such as corticosteroids and beta-blockers
•- Exercising more than 4 hours vigorously per regular week

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