Randomized Assessment of Conventional Neuronavigation versus Intraoperative MRI for the Neurosurgical Treatment of Glioblastomas

Completed

• Conditions: glioblastoma multiforme (GBM); malignant brain tumor; 10029211

• Registration Number: NL-OMON35324
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 27

Inclusion Criteria

* supratentorial brain tumor, on contrast enhanced dMRI suspected to be GBM
* indication for gross total resection (GTR) of the tumor
* age *18 years
* WHO Performance Scale * 2
* ASA class * 3
* adequate knowledge of the Dutch or French language
* informed consent

Exclusion Criteria

- recurrent brain tumor
- multiple brain tumor localizations
- earlier skull radiotherapy
- earlier chemotherapy for GBM
- Chronic Kidney Disease or other renal function disorder
- known MR-contrast allergy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>For each treatment group the percentage of residual tumor as visible on the<br /><br>postoperative scan will be compared to tumor volume on the preoperative scan.<br /><br>The main question from the RACING-project is whether iMRI helps to achieve a<br /><br>lower percentage of residual tumor volume compared to cNN. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* complications<br /><br>* clinical performance (WHO Performance Scale) / quality of life<br /><br>* survival</p><br>