Alveolar Ridge Preservation Following Tooth Extraction Using Advanced Platelet Rich Fibrin (A-PRF) Versus Platelet Rich Fibrin (PRF)

Not Applicable

• Conditions: Alveolar Bone Resorption
• Interventions: Procedure: blood clot; Procedure: Advanced platelet rich fibrin (A-PRF); Procedure: Platelet rich fibrin (PRF)

• Registration Number: NCT04434703
• Lead Sponsor: Cairo University

Brief Summary

the aim of this study is clinically and radiographically evaluate the use of advance platelet rich fibrin (A-PRF) versus platelet rich fibrin (PRF) in preservation of alveolar ridge following tooth extraction

Detailed Description

systemically healthy patients who have at least one non-restorable tooth in the upper inter-bicuspid region and are not seeking immediate or early implant treatment will be allocated in this study after performing nonsurgical periodontal therapy and preoperative periapical therapy to evaluate and improve the condition of the periodontal tissues.

Anesthesia will be given then flapless atraumatic extraction using periotomes followed by forceps after luxation. For all groups, the socket will be debrided using curette then

* group A, the socket will be filled with A.PRF

* group B the socket will be filled with PRF.

* group C no bio-additive will be added.

* Criss cross horizontal mattress suture will be applied to close the extraction wound.

PRF and A-PRF preparation :

10 ml of blood will be drawn from each patient by vein puncture of the antecubital vein.

* Plateletr ich fibrin (PRF) is 3000 rpm and 10 minutes without addition of anticoagulant

* Advanced platelet rich fibrin (A-PRF) is 1300 rpm and 8 minutes.

Study Timeline

• Study First Submitted: 2020-06-13
• Study First Submitted QC: 2020-06-13
• Study First Posted: 2020-06-17
• Study Start: 2020-11-01
• Status Verified: 2021-01
• Last Update Submitted: 2021-01-28
• Last Update Posted: 2021-01-29
• Primary Completion: 2021-07-01
• Study Completion: 2021-09-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients with at least one non restorable tooth in upper inter-bicuspid region.
• Stable periodontal condition with no acute periapical infection.
• Systematically healthy conditions.
• Cooperative patients.
• Intact buccal plate of bone.

Exclusion Criteria

• Smokers.
• Patients seeking immediate or early implants.
• Pregnant females.
• Bone diseases.
• Drugs and diseases that may affect platelet count or function.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
blood clot	blood clot	normal healing of the wound without adding any biomaterial
Advanced platelet rich fibrin (A-PRF)	Advanced platelet rich fibrin (A-PRF)	Advanced platelet rich fibrin is the last modification of PRF which is expected to contain a relatively greater number of white blood cellsand growth factors
Platelet rich fibrin (PRF)	Platelet rich fibrin (PRF)	Platelet rich fibrin is the secoond generation of platelet concentrates which is an autogenous biomaterial that is prepared from the patient's own blood

Primary Outcome Measures

Name	Time	Method
Change in bucco-lingual dimensions	6 months	clinical measurement using bone caliper in mm numerical

Secondary Outcome Measures

Name	Time	Method
bone dentistry	6 months	radiographic measurement using CBCT
postoperative pain scores	2 weeks	clinical measurement using VAS scale in numerical where No pain (0-4 mm) - mild pain (5-44 mm) -moderate pain (45-74 mm), and severe pain (75- 100 mm).
change in alveolar bone height	6 months	radiographic measurement using CBCT in mm numerical
soft tissue healing	6 months	clinical measurement using landr et al index (healing index) in numerical

Trial Locations

Locations (1)

School of dentistry , Cairo University; 🇪🇬 Cairo, Egypt